非咪唑类H(3)受体配体的构效关系。第2部分：对D-氨基酸基序的结合偏好性。

Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 2: binding preference for D-amino acids motifs.

作者信息

Faghih Ramin, Dwight Wesley, Black Larry, Liu Huaqing, Gentles Robert, Phelan Kathleen, Esbenshade Timothy A, Ireland Lynne, Miller Thomas R, Kang Chae-Hee, Krueger Kathy M, Fox Gerard B, Hancock Arthur A, Bennani Youssef L

机构信息

Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6123, USA.

出版信息

Bioorg Med Chem Lett. 2002 Aug 5;12(15):2035-7. doi: 10.1016/s0960-894x(02)00310-4.

DOI:10.1016/s0960-894x(02)00310-4

PMID:12113836

Abstract

Structure-activity relationship studies on novel non-imidazole, D-amino acid containing ligands of histamine 3 receptors are presented. A-304121 is a D-alanine piperazine amide with high affinity at the rat H(3) receptor.

摘要

本文介绍了新型非咪唑类含D-氨基酸的组胺3受体配体的构效关系研究。A-304121是一种D-丙氨酸哌嗪酰胺，对大鼠H(3)受体具有高亲和力。