恰菲埃立克体的omp-1主要外膜多基因家族在犬类和蜱类宿主中差异表达。
The omp-1 major outer membrane multigene family of Ehrlichia chaffeensis is differentially expressed in canine and tick hosts.
作者信息
Unver Ahmet, Rikihisa Yasuko, Stich Roger W, Ohashi Norio, Felek Suleyman
机构信息
Department of Veterinary Biosciences, The Ohio State University, Columbus 43210-1093, USA.
出版信息
Infect Immun. 2002 Aug;70(8):4701-4. doi: 10.1128/IAI.70.8.4701-4704.2002.
Abstract
Sixteen of 22 omp-1 paralogs encoding 28-kDa-range immunodominant outer membrane proteins of Ehrlichia chaffeensis were transcribed in blood monocytes of dogs throughout a 56-day infection period. Only one paralog was transcribed by E. chaffeensis in three developmental stages of Amblyomma americanum ticks before or after E. chaffeensis transmission to naïve dogs.
摘要
在长达56天的感染期内，犬埃立克体编码28 kDa范围免疫显性外膜蛋白的22个omp - 1旁系同源基因中有16个在犬血液单核细胞中被转录。在犬埃立克体传播给未感染的犬之前或之后，美洲钝眼蜱的三个发育阶段中，犬埃立克体仅转录了一个旁系同源基因。
相似文献
1
The omp-1 major outer membrane multigene family of Ehrlichia chaffeensis is differentially expressed in canine and tick hosts.
Infect Immun. 2002 Aug;70(8):4701-4. doi: 10.1128/IAI.70.8.4701-4704.2002.
2
Efficacy and Immune Correlates of OMP-1B and VirB2-4 Vaccines for Protection of Dogs from Tick Transmission of Ehrlichia chaffeensis.
mBio. 2022 Dec 20;13(6):e0214022. doi: 10.1128/mbio.02140-22. Epub 2022 Nov 7.
3
Unique macrophage and tick cell-specific protein expression from the p28/p30-outer membrane protein multigene locus in Ehrlichia chaffeensis and Ehrlichia canis.
Cell Microbiol. 2006 Sep;8(9):1475-87. doi: 10.1111/j.1462-5822.2006.00727.x.
4
Transcriptional analysis of p30 major outer membrane multigene family of Ehrlichia canis in dogs, ticks, and cell culture at different temperatures.
Infect Immun. 2001 Oct;69(10):6172-8. doi: 10.1128/IAI.69.10.6172-6178.2001.
5
An Entry-Triggering Protein of Is a New Vaccine Candidate against Tick-Borne Human Monocytic Ehrlichiosis.
mBio. 2020 Jul 28;11(4):e00895-20. doi: 10.1128/mBio.00895-20.
6
Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family.
Infect Immun. 1998 Jan;66(1):132-9. doi: 10.1128/IAI.66.1.132-139.1998.
7
Amblyomma americanum ticks infected with in vitro cultured wild-type and mutants of Ehrlichia chaffeensis are competent to produce infection in naïve deer and dogs.
Ticks Tick Borne Dis. 2017 Jan;8(1):60-64. doi: 10.1016/j.ttbdis.2016.09.017. Epub 2016 Sep 28.
8
Multiple Ehrlichia chaffeensis Genes Critical for Its Persistent Infection in a Vertebrate Host Are Identified by Random Mutagenesis Coupled with Infection Assessment.
Infect Immun. 2020 Sep 18;88(10). doi: 10.1128/IAI.00316-20.
9
Analysis of transcriptionally active gene clusters of major outer membrane protein multigene family in Ehrlichia canis and E. chaffeensis.
Infect Immun. 2001 Apr;69(4):2083-91. doi: 10.1128/IAI.69.4.2083-2091.2001.
10
Promoter analysis of macrophage- and tick cell-specific differentially expressed Ehrlichia chaffeensis p28-Omp genes.
BMC Microbiol. 2009 May 19;9:99. doi: 10.1186/1471-2180-9-99.
引用本文的文献
1
Multiple genes critical for persistent infection in a vertebrate host are identified as nonessential for its growth in the tick vector; .
Front Cell Infect Microbiol. 2023 Jun 27;13:1220025. doi: 10.3389/fcimb.2023.1220025. eCollection 2023.
2
Efficacy and Immune Correlates of OMP-1B and VirB2-4 Vaccines for Protection of Dogs from Tick Transmission of Ehrlichia chaffeensis.
mBio. 2022 Dec 20;13(6):e0214022. doi: 10.1128/mbio.02140-22. Epub 2022 Nov 7.
3
How relevant are in vitro culture models for study of tick-pathogen interactions?
Pathog Glob Health. 2021 Oct-Dec;115(7-8):437-455. doi: 10.1080/20477724.2021.1944539. Epub 2021 Jun 30.
4
Recent advances in understanding tick and rickettsiae interactions.
Parasite Immunol. 2021 May;43(5):e12830. doi: 10.1111/pim.12830. Epub 2021 Apr 15.
5
Insights into the mechanism regulating the differential expression of the P28-OMP outer membrane proteins in obligatory intracellular pathogen .
Emerg Microbes Infect. 2021 Dec;10(1):461-471. doi: 10.1080/22221751.2021.1899054.
6
Comparative Analysis of Genome of Ehrlichia sp. HF, a Model Bacterium to Study Fatal Human Ehrlichiosis.
BMC Genomics. 2021 Jan 6;22(1):11. doi: 10.1186/s12864-020-07309-z.
7
Multiple Ehrlichia chaffeensis Genes Critical for Its Persistent Infection in a Vertebrate Host Are Identified by Random Mutagenesis Coupled with Infection Assessment.
Infect Immun. 2020 Sep 18;88(10). doi: 10.1128/IAI.00316-20.
8
An Entry-Triggering Protein of Is a New Vaccine Candidate against Tick-Borne Human Monocytic Ehrlichiosis.
mBio. 2020 Jul 28;11(4):e00895-20. doi: 10.1128/mBio.00895-20.
9
Discovery of Virulence Genes of Obligatory Intracellular Bacteria by Random Mutagenesis.
Front Cell Infect Microbiol. 2020 Feb 4;10:2. doi: 10.3389/fcimb.2020.00002. eCollection 2020.
10
Sequence Determinants Spanning -10 Motif and Spacer Region Implicated in Unique Sigma 32-Dependent Promoter Activity of Gene.
Front Microbiol. 2019 Aug 2;10:1772. doi: 10.3389/fmicb.2019.01772. eCollection 2019.
本文引用的文献
1
Transcriptional analysis of p30 major outer membrane multigene family of Ehrlichia canis in dogs, ticks, and cell culture at different temperatures.
Infect Immun. 2001 Oct;69(10):6172-8. doi: 10.1128/IAI.69.10.6172-6178.2001.
2
Analysis of transcriptionally active gene clusters of major outer membrane protein multigene family in Ehrlichia canis and E. chaffeensis.
Infect Immun. 2001 Apr;69(4):2083-91. doi: 10.1128/IAI.69.4.2083-2091.2001.
3
Sensitive detection of Ehrlichia chaffeensis in cell culture, blood, and tick specimens by reverse transcription-PCR.
J Clin Microbiol. 2001 Feb;39(2):460-3. doi: 10.1128/JCM.39.2.460-463.2001.
4
Detection of Ehrlichia chaffeensis DNA in Amblyomma americanum ticks in Connecticut and Rhode Island.
J Clin Microbiol. 2000 Dec;38(12):4655-6. doi: 10.1128/JCM.38.12.4655-4656.2000.
5
Distribution of Ehrlichia chaffeensis (Rickettsiales: Rickettsiaeceae) in Amblyomma americanum in southern Indiana and prevalence of E. chaffeensis--reactive antibodies in white-tailed deer in Indiana and Ohio in 1998.
J Med Entomol. 2000 Jul;37(4):595-600. doi: 10.1603/0022-2585-37.4.595.
6
Ehrlichia chaffeensis antibodies in white-tailed deer, Iowa, 1994 and 1996.
Emerg Infect Dis. 2000 Jul-Aug;6(4):397-400. doi: 10.3201/eid0604.000414.
7
Prevalence of Ehrlichia chaffeensis (Rickettsiales: Rickettsiaceae) in Amblyomma americanum (Acari: Ixodidae) from the Georgia coast and Barrier Islands.
J Med Entomol. 2000 Mar;37(2):276-80. doi: 10.1603/0022-2585-37.2.276.
8
Clinical and biological aspects of infection caused by Ehrlichia chaffeensis.
Microbes Infect. 1999 Apr;1(5):367-76. doi: 10.1016/s1286-4579(99)80053-7.
9
Infection rates of Amblyomma americanum (Acari: Ixodidae) by Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) and prevalence of E. chaffeensis-reactive antibodies in white-tailed deer in southern Indiana, 1997.
J Med Entomol. 1999 Nov;36(6):715-9. doi: 10.1093/jmedent/36.6.715.
10
Coinfection with multiple tick-borne pathogens in a Walker Hound kennel in North Carolina.
J Clin Microbiol. 1999 Aug;37(8):2631-8. doi: 10.1128/JCM.37.8.2631-2638.1999.
Zotero 插件