地中海贫血患者血浆内皮素-1（ET-1）的基线水平及输血过程中的变化。

Baseline levels of plasma endothelin-1 (ET-1) and changes during transfusion in thalassemic patients.

作者信息

Viprakasit Vip, Kankirawatana Suthida, Akarasereenont Pravit, Durongpisitkul Kritvikrom, Chotewuttakorn Sirikul, Tanphaichitr Voravarn S

机构信息

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, United Kingdom.

出版信息

Am J Hematol. 2002 Jul;70(3):260-2. doi: 10.1002/ajh.10129.

DOI:10.1002/ajh.10129

PMID:12118430

Abstract

We studied levels of plasma endothelin-1 (ET-1) in 25 beta-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 +/- 2.1 pg/mL vs. 8.9 +/- 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to slightly increase during the first 24 hr but significantly decline at the 7th day to levels (8.01 +/- 1.7 pg/mL) which do not differ from those of controls. This study highlights a different alteration of plasma ET-1 in patients with beta-thalassemia compared to that of patients with sickle-cell anemia.

摘要

我们研究了25例β地中海贫血/Hb E患者输血前后的血浆内皮素-1（ET-1）水平。这些患者的基线ET-1水平显著高于正常对照组（10.17±2.1 pg/mL对8.9±2.0 pg/mL，P<0.05）。输血后，血浆ET-1水平在最初24小时内有轻微升高趋势，但在第7天显著下降至（8.01±1.7 pg/mL）与对照组无差异的水平。这项研究突出了β地中海贫血患者与镰状细胞贫血患者血浆ET-1的不同变化。