补体受体3（CR3，CD11b/CD18）和补体受体4（CR4，CD11c/CD18）参与不依赖补体的抗体介导的新型隐球菌吞噬作用。
CR3 (CD11b/CD18) and CR4 (CD11c/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans.
作者信息
Taborda Carlos P, Casadevall Arturo
机构信息
Division of Infectious Diseases, The Department of Medicine and The Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
Immunity. 2002 Jun;16(6):791-802. doi: 10.1016/s1074-7613(02)00328-x.
IgM and IgA to the Cryptococcus neoformans capsular glucuronoxylomannan (GXM) promote complement-independent phagocytosis by macrophages with efficiency comparable to that of IgG1. IgM- and IgA-mediated phagocytosis of C. neoformans was proportional to CR3 expression, inhibited by Abs to CR3 (CD11b/CD18) and CR4 (CD11c/CD18), and dramatically reduced with macrophages of CD18-deficient mice. IgM and IgA promoted ingestion of yeast cells by CHO cells expressing CR3 and CR4. In contrast, IgG1-mediated phagocytosis was only partially inhibited by Abs to CR3 and CR4. Phagocytosis by IgM and IgA but not IgG1 was inhibited by soluble GXM, which binds CD18. Involvement of CR in antibody-mediated complement-independent phagocytosis indicates a new link between innate and adaptive immune systems.
针对新型隐球菌荚膜葡糖醛酸木聚糖甘露聚糖（GXM）的IgM和IgA可促进巨噬细胞进行不依赖补体的吞噬作用，其效率与IgG1相当。IgM和IgA介导的新型隐球菌吞噬作用与CR3表达成正比，可被抗CR3（CD11b/CD18）和CR4（CD11c/CD18）的抗体抑制，并且在CD18缺陷小鼠的巨噬细胞中显著降低。IgM和IgA促进表达CR3和CR4的CHO细胞摄取酵母细胞。相比之下，IgG1介导的吞噬作用仅部分被抗CR3和CR4的抗体抑制。IgM和IgA而非IgG1介导的吞噬作用可被结合CD18的可溶性GXM抑制。补体受体参与抗体介导的不依赖补体的吞噬作用表明天然免疫系统和适应性免疫系统之间存在新的联系。
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