阿托伐他汀对正常饮食家兔血液流变学参数的影响。

The effect of atorvastatin on hemorheological parameters in rabbits fed on a normal diet.

作者信息

Cefle Kivanc, Tamer Sule, Kaymaz Alev A, Balci Merih, Ahmetov Semiha, Palanduz Sukru, Ozturk Sukru, Salmayenli Nihal, Onar Vedat

机构信息

Division of Medical Genetics, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

出版信息

Clin Hemorheol Microcirc. 2002;26(4):265-71.

PMID:12122232

Abstract

The effects of statins have been investigated mostly in hyperlipidemic states so far. We analysed blood cholesterol, triglyceride, albumin, fibrinogen and gammaglobulin levels, haematocrite, hemoglobin, erythrocyte, leukocyte and platelet counts, blood and plasma viscosity and erythrocyte rigidity in 12 rabbits fed on a normal diet (chow) which were given 1 mg/kg/day atorvastatin for 4 weeks. Compared to the baseline levels, erythrocyte rigidity (k=0.12+/-0.05 vs. k=0.7+/-0.02) and gammaglobulin levels (1.03+/-0.23 g/dl vs. 0.78+/-0.27 g/dl) decreased significantly (p=0.008 and p=0.025, respectively). Blood lipids, hematological variables, blood and plasma viscosity did not change statistically. Our findings imply that in a normolipemic state, statins given in low doses may improve erythrocyte rigidity without altering blood lipids in short term. Decreased plasma gammaglobulin levels may be reflecting their immunomodulatory effects.

摘要

迄今为止，他汀类药物的作用大多是在高脂血症状态下进行研究的。我们分析了12只正常饮食（普通饲料）的兔子的血胆固醇、甘油三酯、白蛋白、纤维蛋白原和γ球蛋白水平、血细胞比容、血红蛋白、红细胞、白细胞和血小板计数、血液和血浆粘度以及红细胞刚性，这些兔子接受了1毫克/千克/天的阿托伐他汀治疗4周。与基线水平相比，红细胞刚性（k = 0.12±0.05对k = 0.7±0.02）和γ球蛋白水平（1.03±0.23克/分升对0.78±0.27克/分升）显著降低（分别为p = 0.008和p = 0.025）。血脂、血液学变量、血液和血浆粘度没有统计学变化。我们的研究结果表明，在正常血脂状态下，低剂量给予他汀类药物可能在短期内改善红细胞刚性而不改变血脂。血浆γ球蛋白水平降低可能反映了它们的免疫调节作用。