Baker Danial E
College of Pharmacy, Washington State University, Spokane, WA, USA.
Rev Gastroenterol Disord. 2002;2(2):75-86.
Imatinib is an example of a new group of drugs being developed using the principle of molecular targeting. Imatinib is able to kill the cancer cells and not the body's healthy cells. Imatinib mesylate is indicated for the treatment of patients with Kit (CD117)-positive unresectable and/or metastatic malignant gastrointestinal stromal tumors and patients with Philadelphia chromosome-positive chronic myeloid leukemia in blast crisis, accelerated phase, or in chronic phase after failure of interferon-alfa.
伊马替尼是利用分子靶向原理研发的一类新型药物的代表。伊马替尼能够杀死癌细胞,而不会损害人体的健康细胞。甲磺酸伊马替尼适用于治疗患有KIT(CD117)阳性、不可切除和/或转移性恶性胃肠道间质瘤的患者,以及患有费城染色体阳性的慢性髓性白血病处于急变期、加速期或α干扰素治疗失败后的慢性期的患者。