Migliori Marina, Tomassetti Paola, Lalli Sergio, Casadei Riccardo, Santini Donatella, Corinaldesi Roberto, Gullo Lucio
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy.
Pancreatology. 2002;2(2):163-6. doi: 10.1159/000055907.
Pancreatic carcinoids are very rare and usually have a poor prognosis. We describe a case of a pancreatic carcinoid with liver micrometastases in a female of 54 years of age in whom the tumor was without pronounced symptoms apart from rare episodes of flushing. The patient had been treated since November 1995 with the somatostatin analogue octreotide 200 micrograms twice daily for the first 2 years, with the long-acting analogue lanreotide 30 mg every 10 days for the following year, and then with octreotide LAR 20 mg every 28 days until the present. The flushing episodes disappeared completely, and the patient was well. Moreover, the dimensions of the tumor and the liver micrometastases remained stable during the observation period. As far as we known, this is the first case of a pancreatic carcinoid treated successfully with somatostatin analogues and having a satisfactory prognosis.
胰腺类癌非常罕见,预后通常较差。我们描述了一例54岁女性胰腺类癌伴肝微转移的病例,该肿瘤除了偶尔出现潮红外,没有明显症状。自1995年11月起,该患者在前两年每天两次接受200微克生长抑素类似物奥曲肽治疗,次年每10天接受30毫克长效类似物兰瑞肽治疗,然后每28天接受20毫克奥曲肽长效释放制剂治疗直至目前。潮红发作完全消失,患者情况良好。此外,在观察期内肿瘤及肝微转移灶的大小保持稳定。据我们所知,这是首例用生长抑素类似物成功治疗且预后良好的胰腺类癌病例。