Kiprov D, Somova L
Cor Vasa. 1975;17(4):292-301.
The action of prostaglandins of the E and A groups on isolated aortic smooth muscle strips of rats with spontaneous hypertension (Okamoto-Aoki) (SHR) was investigated in order to follow up whether, and to what extent, an alteration of vascular reactivity exists in this model of hypertension, as well as to test the effect of vasodepressor prostaglandins on vessels of spontaneously hypertensive rats. The experiments were carried out on aortic strips of 10 control normotensive rats, and of 10 SHR. The contractions of the isolated vessel strips were recorded by means of an induction coil displacement transducer on an ink-writing electron compensated registration device. The results of the study indicate that the isolated aortic strips of normotensive rats and of SHR respond by contraction to the action of vasodepressor prostaglandins, i.e. paradoxically. It was also established that the reactivity of the isolated aortic strip of SHR to vasodepressor prostaglandins is smaller in comparison to the reactivity of the aorta of control normotensive rats. An attempt is made to explain the paradoxical response of isolated aortic strips of normotensive rats, and of SHR. It is pointed out that contrary to studies on the action of angiotensin, in studies on the vasodepressor action of prostaglandins isolated aortic smooth muscle strips cannot be used as an indicator of vascular reactivity, and especially of resistance vessels reactivity, since their response to hypotensive prostaglandins is paradoxical in both normotensive and spontaneously hypertensive rats.
为了探究在这种高血压模型中是否存在血管反应性改变以及改变程度如何，同时测试血管舒张降压前列腺素对自发性高血压大鼠血管的作用，研究了E组和A组前列腺素对自发性高血压（冈本 - 青木）大鼠（SHR）离体主动脉平滑肌条的作用。实验在10只对照正常血压大鼠和10只SHR的主动脉条上进行。通过感应线圈位移传感器在墨水书写电子补偿记录装置上记录离体血管条的收缩情况。研究结果表明，正常血压大鼠和SHR的离体主动脉条对血管舒张降压前列腺素的作用呈收缩反应，即出现矛盾反应。还确定，与对照正常血压大鼠的主动脉反应性相比，SHR离体主动脉条对血管舒张降压前列腺素的反应性较小。试图解释正常血压大鼠和SHR离体主动脉条的矛盾反应。指出与血管紧张素作用的研究相反，在前列腺素血管舒张降压作用的研究中，离体主动脉平滑肌条不能用作血管反应性尤其是阻力血管反应性的指标，因为它们对降压前列腺素的反应在正常血压大鼠和自发性高血压大鼠中都是矛盾的。
