Li Z, Williamson J F
Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri 63110, USA.
J Appl Clin Med Phys. 2002 Summer;3(3):212-7. doi: 10.1120/jacmp.v3i3.2564.
The recent popularity of permanent implants for treatment of prostate cancer has created a large demand for low energy seed sources. Vendors have introduced new source designs to meet this demand. The AAPM has recommended that all low energy interstitial brachytherapy seed sources be subjected to independent dosimetric evaluations, preferably using experimental measurements as well as Monte Carlo calculations. This work presents the results of Thermo-Luminescence Dosimeter (TLD) measurements of dosimetric parameters on the transverse axis of a new 125I seed source, the Source Tech Medical STM1251 125I seed. Experimental measurements were performed in a Solid Water phantom, with the results corrected to values for liquid water using Monte Carlo calculated correction factors. The parameters measured include the dose rate constant and values of the radial dose function at distances of 0.5 cm through 5 cm. The measured dose rate constant in liquid water for the STM1251 125I seed was 1.039 cGy/U-hr. Measured radial dose function values agreed with Monte Carlo calculated ones to within 10%. These measurements therefore confirm the modeling and simulation of Monte Carlo calculations for this 125I source design, within the statistical uncertainties of the calculation and measurement techniques.
近期,用于治疗前列腺癌的永久性植入物广受欢迎,这使得对低能量种子源的需求大增。供应商已推出新的源设计以满足这一需求。美国医学物理师协会(AAPM)建议,所有低能量组织间近距离治疗种子源都应接受独立的剂量学评估,最好同时使用实验测量以及蒙特卡罗计算。本文介绍了对一种新型125I种子源——源科技医疗STM1251 125I种子在横轴上剂量学参数的热释光剂量计(TLD)测量结果。实验测量在固体水模体中进行,结果使用蒙特卡罗计算的校正因子校正为液态水的值。测量的参数包括剂量率常数以及在0.5厘米至5厘米距离处的径向剂量函数值。STM1251 125I种子在液态水中测量的剂量率常数为1.039 cGy/(U·小时)。测量的径向剂量函数值与蒙特卡罗计算值在10%以内相符。因此,在计算和测量技术的统计不确定度范围内,这些测量结果证实了针对这种125I源设计的蒙特卡罗计算的建模和模拟。