Nola Ivana, Kruslin Bozo, Müller Danko, Oremović Lenka, Belicza Mladen
Clinical Department of Dermatovenerology, Sestre milosrdnice University Hospital, Vinogradska cesta 29, 10 000 Zagreb, Croatia.
Acta Dermatovenerol Croat. 2002 Mar;10(1):3-7.
The incidence of skin cancer, and particularly of cutaneous melanoma, has increased substantially over the recent decades. It has generally been assumed that early diagnosis may in fact be responsible for a part of incidence increase. The aim of the study was to analyze the prevalence and distribution of primary cutaneous melanoma among biopsy specimens during the 1991-2000 period. The Surgical Pathology computerized registry was used to identify patients with primary cutaneous melanoma. The distribution of primary cutaneous melanoma according to Clark showed an increased number of melanoma in situ diagnosed during the 1997-2000 period. It could not be definitely concluded whether these data resulted from more common excision of suspicious pigmented skin lesions or there was an increase in the melanoma rate as a consequence of environmental changes. Fortunately, nowadays new patients with cutaneous melanoma are mostly diagnosed early in the clinical course of disease when it can be successfully managed by simple surgical treatment.
近几十年来，皮肤癌尤其是皮肤黑色素瘤的发病率大幅上升。一般认为，早期诊断实际上可能是发病率上升的部分原因。本研究的目的是分析1991年至2000年期间活检标本中原发性皮肤黑色素瘤的患病率和分布情况。利用外科病理学计算机登记系统来识别原发性皮肤黑色素瘤患者。根据克拉克分级法，原发性皮肤黑色素瘤的分布显示，1997年至2000年期间原位黑色素瘤的诊断数量有所增加。无法确切得出这些数据是由于对可疑色素沉着性皮肤病变进行了更普遍的切除，还是由于环境变化导致黑色素瘤发病率上升。幸运的是，如今新诊断出的皮肤黑色素瘤患者大多在疾病临床过程的早期被诊断出来，此时通过简单的手术治疗就能成功治愈。
