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[现代金属网状支架用于气管支气管狭窄的多学科介入治疗]

[Interdisciplinary interventional therapy for tracheobronchial stenosis with modern metal net stents].

作者信息

Rieger J, Linsenmaier U, Hautmann H, Fedorowski A, Huber R M, Pfeifer K J

机构信息

Institut für Klinische Radiologie, Ludwig-Maximilians-Universität München, Germany.

出版信息

Rofo. 2002 Aug;174(8):1009-14. doi: 10.1055/s-2002-32932.

Abstract

STUDY OBJECTIVES

Assessment of the therapeutic potential of tracheobronchial stenting for obstructive tracheobronchial disease, in-vivo comparison of different stent types and development of helpful criteria for choosing the suitable stent type.

MATERIAL AND METHODS

Prospective case analysis. Between 1993 and 1999 53 stents were implanted into the tracheobronchial system of 39 consecutive patients with benign or malignant airway obstruction. Every single stent (26 Strecker Stents, 18 Wallstents, 6 Accuflex Nitinolstents, 1 Dumon-, 1 Rüsch- and 1 Palmazstent) was recorded in an unified database. Analysis comprised clinical effectiveness, lung function if possible, relevant complications and radiologic follow-up parameters. The probability of their remaining within the tracheobronchial system, of their remaining undislocated and uncompressed was calculated using Kaplan-Meier analysis for three stent types.

RESULTS

Stent placement proved itself to be an effective treatment in 86 % of the patients. Resistance could be normalized in 9/9 patients. Kaplan-Meier analysis clearly revealed a higher probability for the Wall- and Nitinolstent to remain within the tracheobronchial system and to remain uncompressed. Dislocation also occurred more rarely. Explantation of the Wallstent, however, if desired, was much more difficult compared to the Strecker stent. The Wallstent also occasionally led to the formation of granulation tissue especially at the proximal stent end and, as such, required reintervention.

CONCLUSION

Any of the 3 stent types proved to be an effective therapeutic option in the management of obstructive tracheobronchial disease. Choise of the stent type should be determined through definition of the therapeutic intention. It is useful to distinguish between (a) benign stenosis, (b) malignant stenosis but curative therapeutic situation and (c) malignant stenosis in a palliative therapeutic situation with limited life expectancy. In spite of its superior mechanical properties the Wallstent is rather suited for a palliative situation because explantation may be difficult. The Strecker Stent requires more reinterventions but removal is easy to perform. The Nitinolstent possibly represents a reasonable compromise.

摘要

研究目的

评估气管支气管支架置入术治疗阻塞性气管支气管疾病的潜力,对不同类型支架进行体内比较,并制定选择合适支架类型的有用标准。

材料与方法

前瞻性病例分析。1993年至1999年间,为39例连续性良性或恶性气道阻塞患者的气管支气管系统植入了53个支架。每个支架(26个施特雷克支架、18个华尔支架、6个阿库弗莱克斯镍钛诺支架、1个杜蒙支架、1个鲁施支架和1个帕尔马兹支架)都记录在一个统一的数据库中。分析包括临床疗效、可能的肺功能、相关并发症和放射学随访参数。使用Kaplan-Meier分析计算三种支架类型留在气管支气管系统内、保持无移位和无压缩的概率。

结果

支架置入术在86%的患者中被证明是一种有效的治疗方法。9例患者的阻力恢复正常。Kaplan-Meier分析清楚地显示,华尔支架和镍钛诺支架留在气管支气管系统内且保持无压缩的概率更高。移位也较少发生。然而,与施特雷克支架相比,如需取出华尔支架则困难得多。华尔支架偶尔还会导致肉芽组织形成,尤其是在支架近端,因此需要再次干预。

结论

三种支架类型中的任何一种在治疗阻塞性气管支气管疾病方面都被证明是一种有效的治疗选择。支架类型的选择应根据治疗目的来确定。区分以下情况是有用的:(a)良性狭窄;(b)恶性狭窄但处于可治愈的治疗情况;(c)预期寿命有限的姑息治疗情况下的恶性狭窄。尽管华尔支架具有优越的机械性能,但因其取出可能困难,所以更适合姑息治疗情况。施特雷克支架需要更多的再次干预,但取出操作容易。镍钛诺支架可能是一个合理的折衷方案。

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