艰难梭菌相关性腹泻与慢性肾功能不全。
Clostridium difficile-associated diarrhea and chronic renal insufficiency.
作者信息
Yousuf Khurshid, Saklayen Mohammad G, Markert Ronald J, Barde Christopher J, Gopalswamy Narasimh
机构信息
Veterans Affairs Medical Center and the Deaprtment of Medicine, Wright State University, Dayton Ohio, USA.
出版信息
South Med J. 2002 Jul;95(7):681-3.
BACKGROUND
Clostridium difficile-associated diarrhea (CDAD) is a common cause of mortality and morbidity in hospitalized patients. Some case reports have implicated renal failure as a risk factor for CDAD. The aim of this study was to assess whether chronic renal insufficiency is a risk factor for CDAD and whether it increases mortality and morbidity.
METHOD
We reviewed charts of 385 patients with diarrhea for CDAD, chronic renal insufficiency, mortality, and recurrence of CDAD.
RESULTS
Seventy-seven patients had infection due to C difficile. There was no difference in the chronic renal insufficiency, mortality, and other comorbid conditions between patients who had C difficile infection and those who did not. The patients with CDAD and chronic renal insufficiency had significantly higher mortality and recurrence of CDAD than patients without chronic renal insufficiency.
CONCLUSIONS
Chronic renal insufficiency is not a risk factor for CDAD, but its presence with CDAD increases mortality and recurrence of CDAD.
背景
艰难梭菌相关性腹泻（CDAD）是住院患者死亡和发病的常见原因。一些病例报告认为肾衰竭是CDAD的一个危险因素。本研究的目的是评估慢性肾功能不全是否为CDAD的危险因素，以及它是否会增加死亡率和发病率。
方法
我们回顾了385例腹泻患者的病历，以了解CDAD、慢性肾功能不全、死亡率和CDAD复发情况。
结果
77例患者感染了艰难梭菌。感染艰难梭菌的患者与未感染的患者在慢性肾功能不全、死亡率和其他合并症方面没有差异。与无慢性肾功能不全的患者相比，患有CDAD和慢性肾功能不全的患者死亡率和CDAD复发率显著更高。
结论
慢性肾功能不全不是CDAD的危险因素，但它与CDAD并存会增加CDAD的死亡率和复发率。
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