Perez Ruiz L, Marco Estarreado L, Guidolin D, Del Carmen Garcés Guallart M
Facoltà di Medicina, Ospedale Universitario Arnau de Vilanova, Lleida, Servizio di Chirugia Generale, Università degli Studi, Lleida, Spagna.
Minerva Chir. 2002 Aug;57(4):489-94.
The goal of this study is to compare the usual surgical technique with the use of fibrin glue, which is faster to perform and has few histological alterations in the anastomosis.
We performed 70 microanastomoses on the internal jugular vein of the Sprague-Dawley rats, and we estimated: immediate and late permeability and postoperative complication. Besides, we made a histological study of all the anastomoses on the 15th day and after one month of the intervention.
The middletime request to practise the microanastomosis is significantly shorter when using the fibrin glue. The late permeability rate with standard suture is 97 and 77% with fibrin glue. The number of complications is similar, even if we found a 14.7% rate of aneurysms in the anastomosis with fibrin glue. The histological study showed few alterations to the vascular wall in the fibrin seal group and a great permanent histopathological alteration in the standard technique.
The use of fibrin glue is a very good technique for this kind of microanastomosis. It is fast to perform, has few histological alterations and a similar permeability rate although careful approximation of the vascular edges is necessary to get a good anastomosis.
本研究的目的是比较常规手术技术与使用纤维蛋白胶的情况，后者操作更快，吻合处的组织学改变较少。
我们在Sprague-Dawley大鼠的颈内静脉上进行了70次显微吻合，并评估了：即时和后期的通畅性以及术后并发症。此外，我们在干预后的第15天和1个月对所有吻合处进行了组织学研究。
使用纤维蛋白胶时，进行显微吻合的平均时间要求明显更短。标准缝合的后期通畅率为97%，纤维蛋白胶为77%。并发症数量相似，尽管我们在使用纤维蛋白胶的吻合处发现了14.7%的动脉瘤发生率。组织学研究显示，纤维蛋白封闭组血管壁的改变较少，而标准技术组有明显的永久性组织病理学改变。
对于这种显微吻合，使用纤维蛋白胶是一种非常好的技术。它操作快速，组织学改变少，通畅率相似，尽管为了获得良好的吻合，需要仔细对合血管边缘。
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