[脂肪酶催化外消旋苯甘氨酸甲酯在有机溶剂中的对映选择性氨解反应]
[Lipase-catalyzed enantioselective ammonolysis of racemic phenylglycine methyl ester in organic solvent].
作者信息
Du Wei, Zong Min-Hua, Guo Yong, He Jun, Zhang Yuan-Yuan, Xie Zhao-Lin, Lou Wen-Yong
机构信息
Biotechnology Department, South China University of Technology, Guangzhou 510640, China.
出版信息
Sheng Wu Gong Cheng Xue Bao. 2002 Jan;18(2):242-5.
A novel reaction-enzymatic ammonolysis discovered in the mid of 1990s has been demonstrated to be a very promising alternative in the preparation of optically pure compounds. The effects of organic solvent, initial water activity, temperature and additives on lipase Novozym435-catalyzed enantioselective ammonolysis of racemic phenylglycine methyl ester were investigated systematically in this paper. Enzymatic reaction of ammonolysis showed higher activity and enantioselectivity than the corresponding reaction of hydrolysis and alcoholysis.
20世纪90年代中期发现的一种新型反应——酶促氨解反应，已被证明是制备光学纯化合物的一种非常有前景的替代方法。本文系统研究了有机溶剂、初始水分活度、温度和添加剂对脂肪酶Novozym435催化外消旋苯甘氨酸甲酯对映选择性氨解反应的影响。氨解酶促反应比相应的水解和醇解反应表现出更高的活性和对映选择性。
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