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[原发性心脏淋巴瘤:细胞诊断及多药化疗与造血前体自体移植治疗反应。病例报告及文献综述]

[Primary cardiac lymphoma: cytological diagnosis and treatment with response to polychemotherapy and hematopoietic precursor autotransplant. Presentation of a case a review of the literature].

作者信息

Porcar Ramells C, Clemente González C, García Parés D, Guardia Sánchez R, Pérez Ayuso M J, García-Bragado Dalmau F

机构信息

Servicio de Medicina Interna, Hospital Universitari de Girona, Dr. Josep Trueta, C/Av. de França, s/n. 17007-Girona.

出版信息

An Med Interna. 2002 Jun;19(6):305-9.

Abstract

The primary cardiac lymphoma (PCL) is an extremely infrequent tumor suffered by immunocompetent patients with a difficult diagnosis and slow progress leading to a serious prognosis and few therapeutically possibilities. It's a primary-cardiac non-Hodgkin's lymphoma (NHL) in a patient of 46-year-old, immunocompetent, who started with a congestive heart failure and atrial flutter. Some examinations were carried out such as a transesophageal echocardiography (TEE), a computed tomography (TC) and a magnetic resonance imaging (MRI) and an intracardiac tumor placed in the interauricular septum was detected. The diagnosis was based on a pleural fluid cytological examination. It was decided to follow a chemotherapy treatment and the autologous peripheral blood stem cells transplantation was carried out. The patient remains in full remission thirty-six months after diagnosis and twenty-nine months after the autotransplant. Our clinical experience indicated that an early and accurate diagnosis combined with the appropriate and aggressive antilymphoma therapy can thus help in obtaining a long survival in patients with PCL.

摘要

原发性心脏淋巴瘤(PCL)是免疫功能正常患者所患的一种极为罕见的肿瘤,诊断困难,进展缓慢,预后严重,治疗选择有限。这是一名46岁免疫功能正常患者的原发性心脏非霍奇金淋巴瘤(NHL),患者最初表现为充血性心力衰竭和心房颤动。进行了一些检查,如经食管超声心动图(TEE)、计算机断层扫描(CT)和磁共振成像(MRI),发现心房间隔有一个心内肿瘤。诊断基于胸腔积液细胞学检查。决定采用化疗治疗并进行自体外周血干细胞移植。患者在诊断后36个月和自体移植后29个月仍处于完全缓解状态。我们的临床经验表明,早期准确诊断并结合适当积极的抗淋巴瘤治疗有助于PCL患者获得长期生存。

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