Romanovskii D Y, Tyul'kova E I, Samoilov M O
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Bull Exp Biol Med. 2001 Dec;132(6):1154-6. doi: 10.1023/a:1014546928677.
We studied the effect of in vivo exposure to hypobaric hypoxia of different depth on the resistance of neurons in brain slices to 10-min anoxia in vitro. Severe hypoxia simulating ascent to 11,000 m above sea level potentiated the adverse effect of 10-min anoxia and caused profound suppression of synaptic transmission. Moderate preconditioning hypoxia simulating ascent to 5000 m above sea level produced a long-lasting protective effect on synaptic activity.