Bothwell J E, Clarke K, Dooley J M, Gordon K E, Anderson R, Wood E P, Camfield C S, Camfield P R
Department of Pediatrics, Division of Pediatric Neurology, IWK Health Centre, Halifax, Nova Scotia, Canada.
Pediatr Neurol. 2002 Jul;27(1):18-22. doi: 10.1016/s0887-8994(02)00381-8.
Drooling is problematic for some neurologically impaired children. Botulinum toxin A injection to salivary glands has effectively reduced drooling in adults but has only recently been used to treat children. This was a preliminary study to determine the efficacy and safety of botulinum toxin in children. Children identified as having severe daily drooling were enrolled. The preinjection assessment included measurement of the amount and frequency of drool. Each parotid gland was injected with 5 U of botulinum toxin A. Follow-up was for a minimum of 16 weeks. Nine children were enrolled, 4-17 years of age. All children had moderate or severe mental retardation. At week 4, all patients had a reduced drooling frequency and eight of nine patients had a reduction in the weight of saliva. Overall, five of nine parents (55%) deemed the treatment successful. This preliminary study demonstrates that botulinum toxin A is a relatively effective treatment for some children with significant drooling without serious side effects.
流口水对一些神经功能受损的儿童来说是个问题。向唾液腺注射A型肉毒杆菌毒素已有效减少了成人的流口水现象，但直到最近才用于治疗儿童。这是一项确定肉毒杆菌毒素对儿童疗效和安全性的初步研究。招募了被确定为每天严重流口水的儿童。注射前评估包括测量流口水的量和频率。每个腮腺注射5单位A型肉毒杆菌毒素。随访至少16周。招募了9名4至17岁的儿童。所有儿童都有中度或重度智力障碍。在第4周时，所有患者流口水频率降低，9名患者中有8名唾液量减少。总体而言，9名家长中有5名（55%）认为治疗成功。这项初步研究表明，A型肉毒杆菌毒素对一些流口水严重的儿童是一种相对有效的治疗方法，且无严重副作用。
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