印度北部载脂蛋白CII基因座的遗传异质性。

Genetic heterogeneity of Apo CII locus in north India.

作者信息

Singh Puneet Pal, Singh Monica, Mastana Sarabjit S

机构信息

Department of Human Biology, Punjabi University, Patiala, India.

出版信息

Anthropol Anz. 2002 Jun;60(2):161-7.

PMID:12161961

Abstract

Apolipoprotein CII genotypes were determined in Brahmins, Banias, Jat Sikhs, Khatris, Ramgarhia, Ramdasia and Scheduled Castes of Punjab, North India (n = 930). The Apo CII exhibits three common polymorphic alleles CII1, CII2 and CII3 with pooled frequencies 0.883, 0.114 and 0.003, respectively. CII3 was absent in Brahmins. Distribution of Apo CII isoforms highlights a considerable variation among different ethnic groups across the world. The average heterozygosity of the Punjabi populations was 0.208. The gene diversity among these population groups was less than 0.1%.

摘要

在印度北部旁遮普邦的婆罗门、班尼亚斯、贾特锡克教徒、卡特里人、拉姆加尔希亚人、拉姆达西亚人和在册种姓（n = 930）中确定了载脂蛋白CII基因型。载脂蛋白CII表现出三个常见的多态性等位基因CII1、CII2和CII3，其合并频率分别为0.883、0.114和0.003。婆罗门中不存在CII3。载脂蛋白CII同工型的分布突出了世界各地不同种族群体之间的显著差异。旁遮普人群的平均杂合度为0.208。这些人群组之间的基因多样性小于0.1%。