Lee Han N, Pokorny Christopher D, Law Sandra, Pratt Melanie, Sasseville Denis, Storrs Frances J
Department of Dermatology, Oregon Health & Science University, Portland, OR 97201, USA.
Am J Contact Dermat. 2002 Sep;13(3):108-15.
The study's objective was 2-fold: first, to evaluate the potential cross-reactivity between Bis-A epoxy resins and epoxy acrylates and second, to study the cross reactivity between Bis-A epoxy resins and newer Bis-F epoxy resins in patients with allergic contact dermatitis to epoxy resins and had positive patch test to the standard epoxy resin based on bisphenol A.
Forty-one patients were patch tested to 23 chemicals including epoxy acrylates, Bis-A epoxy resins, and Bis-F epoxy resins, as well as reactive diluents and nonbisphenol epoxy resins. Questions concerning exposure to epoxy resins, occupational history, and problems with dental work were completed.
All patients included in the study had positive reactions to the standard Bis-A epoxy resin. Twenty percent (8 of 41) of the patients reacted to at least one of the epoxy acrylates; the most common reaction was to Bis-GMA. Five of 8 patients who reacted to the epoxy acrylates had dental work, but only one patient had problems from her dental work. Six of 8 patients (75%) who reacted to epoxy resins and epoxy acrylates did not react to aliphatic acrylates. Thirty-two percent (13 of 41) reacted to tosylamide epoxy resin, and none reacted to triglycidyl isocyanurate resin. In addition, all patients (100%) had positive reactions to at least one of the Bis-F epoxy resins that were tested.
Most patients with sensitivity to Bis-A epoxy resins do not cross-react with epoxy acrylates. Patients with positive patch test reactions to epoxy acrylates used in dentistry usually do not have symptoms from their dental work. To our knowledge, this is the largest series of patients with sensitivity to the standard Bis-A epoxy resin that have been patch tested with the more recently introduced Bis-F epoxy resins. There is significant cross-reactivity between Bis-A and Bis-F epoxy resins, which can be explained by their structural similarity.
本研究有两个目标：第一，评估双酚A环氧树脂与环氧丙烯酸酯之间的潜在交叉反应性；第二，研究对环氧树脂过敏且对基于双酚A的标准环氧树脂斑贴试验呈阳性的过敏性接触性皮炎患者中，双酚A环氧树脂与新型双酚F环氧树脂之间的交叉反应性。
对41名患者进行了23种化学物质的斑贴试验，这些化学物质包括环氧丙烯酸酯、双酚A环氧树脂和双酚F环氧树脂，以及活性稀释剂和非双酚环氧树脂。完成了有关环氧树脂暴露、职业史和牙科治疗问题的询问。
研究纳入的所有患者对标准双酚A环氧树脂均有阳性反应。20%（41名中的8名）患者对至少一种环氧丙烯酸酯有反应；最常见的反应是对双酚G甲基丙烯酸缩水甘油酯（Bis-GMA）的反应。对环氧丙烯酸酯有反应的8名患者中有5名进行过牙科治疗，但只有1名患者因牙科治疗出现问题。对环氧树脂和环氧丙烯酸酯有反应的8名患者中有6名（75%）对脂肪族丙烯酸酯无反应。32%（41名中的13名）对甲苯磺酰胺环氧树脂有反应，对三缩水甘油基异氰脲酸酯树脂均无反应。此外，所有患者（100%）对所测试的至少一种双酚F环氧树脂有阳性反应。
大多数对双酚A环氧树脂敏感的患者与环氧丙烯酸酯无交叉反应。对牙科中使用的环氧丙烯酸酯斑贴试验呈阳性反应的患者通常不会因牙科治疗出现症状。据我们所知，这是对标准双酚A环氧树脂敏感且用最近引入的双酚F环氧树脂进行斑贴试验的最大系列患者。双酚A和双酚F环氧树脂之间存在显著的交叉反应性，这可以用它们的结构相似性来解释。
Zotero 插件