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5-氟尿嘧啶与低剂量顺铂联合化疗用于晚期和复发性胃癌:日本长崎的一项多中心回顾性研究

Combination chemotherapy of 5-fluorouracil and low-dose cisplatin in advanced and recurrent gastric cancer: a multicenter retrospective study in Nagasaki, Japan.

作者信息

Enjoji Akihito

机构信息

Department of Surgery II, Nagasaki University School of Medicine, Japan.

出版信息

Anticancer Res. 2002 Mar-Apr;22(2B):1135-9.

Abstract

BACKGROUND

Combination therapy consisting of 5-fluorouracil (5-FU) and cisplatin (CDDP) has been shown to be effective in the treatment of gastric cancer.

PATIENTS AND METHODS

The efficacy and safety of the combination therapy consisting of 5-FU and low-dose CDDP were assessed in 37 patients with advanced or recurrent gastric cancer. One course consisted of continuous drip infusion of 5-FU (330 mg/m2/day) on days 1-5 (7) + 5-day drip infusion of CDDP (5 mg/m2/day) for 4 weeks. The patients were treated with at least one course.

RESULTS

The complete response (CR) + partial response (PR) rate was 35.1% and median survival-time (MST) was 7.1 months. There were no grade 3 or more adverse effects.

CONCLUSION

Our results suggest that this mode of combination therapy leads to a fairly favorable outcome with few adverse effects in patients with advanced and recurrent gastric cancer.

摘要

背景

已证明由5-氟尿嘧啶(5-FU)和顺铂(CDDP)组成的联合疗法对胃癌治疗有效。

患者与方法

对37例晚期或复发性胃癌患者评估了由5-FU和低剂量CDDP组成的联合疗法的疗效和安全性。一个疗程包括在第1 - 5天持续滴注5-FU(330mg/m²/天)(共7天)+ 5天滴注CDDP(5mg/m²/天),持续4周。患者接受至少一个疗程的治疗。

结果

完全缓解(CR)+部分缓解(PR)率为35.1%,中位生存时间(MST)为7.1个月。无3级或更严重的不良反应。

结论

我们的结果表明,这种联合治疗模式在晚期和复发性胃癌患者中可带来相当良好的结果,且不良反应较少。

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