213例喉癌患者的临床研究

[A clinical study of 213 patients with laryngeal cancer].

作者信息

Miyahara Hiroshi, Yane Katsunari, Tsuruta Yoshihiro, Uemura Hirokazu

机构信息

Department of Otolaryngology Head and Neck Surgery, Nara Medical University, Nara.

出版信息

Nihon Jibiinkoka Gakkai Kaiho. 2002 Jul;105(7):790-8. doi: 10.3950/jibiinkoka.105.790.

DOI:10.3950/jibiinkoka.105.790

PMID:12174612

Abstract

We retrospectively analyzed 213 patients--197 men and 14 women aged 40 to 87 years--with laryngeal cancer treated at our department from September 1986 to December 1997. The male to female ratio was about 12:1. Cases included 120 glottic (56.3%), 90 supraglottic (42.3%), and 3 subglottic (1.4%). Radiotherapy for early cases and surgery, mainly total laryngectomy for T3 and T4 were conducted first. The 5-year cause-specific survival by site was 97.6% glottic and 77.5% supraglottic. The five-year survival was 88.6% overall. Local control was 83.8% in glottic T1a and 84.6% in glottic T1b. The 3-year preservation of the larynx was 89.1% in glottic T1a and 92.3% in glottic T1b. Distant metastases were observed in 14 cases, mostly to the lung, bones, and liver. At high risk for distant metastasis were those with supraglottic T3-T4, N1, N2b, or pN2c.

摘要

我们回顾性分析了1986年9月至1997年12月在我科接受治疗的213例喉癌患者，其中男性197例，女性14例，年龄在40至87岁之间。男女比例约为12:1。病例包括声门型120例（56.3%）、声门上型90例（42.3%）和声门下型3例（1.4%）。早期病例采用放疗，T3和T4期主要采用全喉切除术。按部位计算的5年病因特异性生存率，声门型为97.6%，声门上型为77.5%。总体5年生存率为88.6%。声门型T1a的局部控制率为83.8%，声门型T1b为84.6%。声门型T1a的喉保留3年率为89.1%，声门型T1b为92.3%。观察到14例远处转移，主要转移至肺、骨和肝。声门上型T3 - T4、N1、N2b或pN2c患者发生远处转移的风险较高。