Chondrocyte senescence and telomere regulation: implications in cartilage aging and cancer (a brief review).
作者信息
Mollano Anthony V, Martin James A, Buckwalter Joseph A
机构信息
Department of Orthopaedics, University of Iowa Hospitals and Clinics Iowa City 52242, USA.
出版信息
Iowa Orthop J. 2002;22:1-7.
Abstract
Recent studies on osteoarthritis and the cartilage aging in our laboratory demonstrate that chronologic age correlates with molecular changes in human chondrocytes that affect cell cycle control and replicative life span. These findings indicate that age-related changes in chondrocytes may explain the heightened risk for development of primary osteoarthritis (OA) with increasing age. Concomitant studies of human chondrosarcoma suggest that these aging mechanisms may also play a role in preventing the malignant transformation of chondrocytes. The convergence at the molecular level of these seemingly dissimilar biologic processes provides an excellent opportunity to deepen our understanding of the fundamental processes underlying cartilage neoplasia, cartilage aging, and osteoarthritis.
摘要
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本文引用的文献
1
ON THE PERMANENT LIFE OF TISSUES OUTSIDE OF THE ORGANISM.
J Exp Med. 1912 May 1;15(5):516-28. doi: 10.1084/jem.15.5.516.
2
The Fusion of Broken Ends of Chromosomes Following Nuclear Fusion.
Proc Natl Acad Sci U S A. 1942 Nov;28(11):458-63. doi: 10.1073/pnas.28.11.458.
3
The serial cultivation of human diploid cell strains.
Exp Cell Res. 1961 Dec;25:585-621. doi: 10.1016/0014-4827(61)90192-6.
4
Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.
J Biol Chem. 2002 May 3;277(18):15566-72. doi: 10.1074/jbc.M201266200. Epub 2002 Feb 19.
5
Repression of telomerase activity during in vitro differentiation of osteosarcoma cells.
Cancer Invest. 2002;20(1):38-45. doi: 10.1081/cnv-120000364.
6
Telomerase as a universal tumor-associated antigen for cancer immunotherapy.
Oncogene. 2002 Jan 21;21(4):674-9. doi: 10.1038/sj.onc.1205074.
7
Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors.
Oncogene. 2002 Jan 21;21(4):638-42. doi: 10.1038/sj.onc.1205064.
8
Between Scylla and Charybdis: p53 links tumor suppression and aging.
Mech Ageing Dev. 2002 Mar 31;123(6):567-73. doi: 10.1016/s0047-6374(02)00006-4.
9
Effects of telomerase and viral oncogene expression on the in vitro growth of human chondrocytes.
J Gerontol A Biol Sci Med Sci. 2002 Feb;57(2):B48-53. doi: 10.1093/gerona/57.2.b48.
10
Roles of articular cartilage aging and chondrocyte senescence in the pathogenesis of osteoarthritis.
Iowa Orthop J. 2001;21:1-7.
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