两个中国人群中不育男性Y染色体微缺失的比较研究。
A comparative study of Y chromosome microdeletions in infertile males from two Chinese populations.
作者信息
Tse J Y M, Yeung W S B, Ng E H Y, Cheng L N, Zhu H B, Teng X M, Liu Y K, Ho P C
机构信息
Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong, People's Republic of China.
出版信息
J Assist Reprod Genet. 2002 Aug;19(8):376-83. doi: 10.1023/a:1016346421177.
PURPOSE
To compare the prevalence and type of Y-microdeletions in Hong Kong and Shanghai men with severe male-factor infertility.
METHODS
Seven Y-linked sequence tagged site (STS) primers and seven gene-specific primers were screened in 293 infertile males (139 from Hong Kong and 154 from Shanghai) and 161 fertile men (61 from Hong Kong and 100 from Shanghai). Serum FSH, LH, and testosterone levels were also measured in these men.
RESULTS
The incidence of Yq microdeletions in nonobstructive azoospermic men from Hong Kong (8.5%) and Shanghai (6%) was similar. Yq microdeletions were observed in severe oligospermic patients (8.5%) from Hong Kong but not from Shanghai. Among the 9 Hong Kong men with Y-microdeletions, 8 had AZFc deletion and one had AZFb deletion. In contrast, 6 of 9 men from Shanghai with Y-microdeletions had AZFb deletion. The incidence of AZFb deletion among Y-microdeleted men was statistically different between the two populations. Two of the men with AZFb deletion also had AZFa and AZFc deletions.
CONCLUSIONS
Regional variations in the type of Y-microdeletion existed between Hong Kong and Shanghai infertile males.
目的
比较香港和上海严重男性因素不育男性中Y微缺失的患病率及类型。
方法
对293名不育男性（139名来自香港，154名来自上海）和161名生育男性（61名来自香港，100名来自上海）进行7种Y连锁序列标签位点（STS）引物和7种基因特异性引物的筛选。还测量了这些男性的血清促卵泡激素（FSH）、促黄体生成素（LH）和睾酮水平。
结果
香港（8.5%）和上海（6%）非梗阻性无精子症男性中Yq微缺失的发生率相似。在香港的严重少精子症患者（8.5%）中观察到Yq微缺失，而上海的此类患者未观察到。在9名有Y微缺失的香港男性中，8名有AZFc缺失，1名有AZFb缺失。相比之下，9名有Y微缺失的上海男性中有6名有AZFb缺失。两个群体中Y微缺失男性中AZFb缺失的发生率在统计学上存在差异。两名有AZFb缺失的男性也有AZFa和AZFc缺失。
结论
香港和上海不育男性中Y微缺失类型存在地区差异。
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