[运动皮层中的突触可塑性]
[Synaptic plasticity in the motor cortex].
作者信息
Hess Grzegorz
机构信息
Instytut Farmakologii PAN w Krakowie.
出版信息
Postepy Hig Med Dosw. 2002;56(3):385-91.
PMID:12194251
Abstract
Horizontally-oriented intracortical connections have been proposed to serve as a substrate for plastic reorganizations of adult motor cortex. N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) of synaptic efficacy is a candidate mechanism of these reorganizations in mammalian species ranging from rats to humans. The acquisition of a motor skill is accompanied by increased strength of synaptic connections within adult rat primary motor cortex, most likely due to LTP-like mechanisms.
摘要
水平方向的皮质内连接被认为是成年运动皮质可塑性重组的基础。在从大鼠到人类的哺乳动物物种中，突触效能依赖于N-甲基-D-天冬氨酸（NMDA）受体的长时程增强（LTP）是这些重组的一种可能机制。运动技能的习得伴随着成年大鼠初级运动皮质内突触连接强度的增加，这很可能是由于类似LTP的机制。
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