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新型和老式抗抑郁药的疗效差异似乎是由年龄对抑郁症表型表达的影响所介导的。

Differential effectiveness of newer and older antidepressants appears mediated by an age effect on the phenotypic expression of depression.

作者信息

Parker G

机构信息

School of Psychiatry, University of New South Wales, and Mood Disorders Unit, Prince of Wales Hospital, Sydney, Australia.

出版信息

Acta Psychiatr Scand. 2002 Sep;106(3):168-70. doi: 10.1034/j.1600-0447.2002.02432.x.

DOI:10.1034/j.1600-0447.2002.02432.x
PMID:12197852
Abstract

OBJECTIVE

A possible mechanism whereby the serotonin reuptake inhibitor (SSRI) antidepressants may not (overall) be as effective as the tricyclic (TCA) antidepressants is explored.

METHOD

Clinical psychiatrists rated the effectiveness of past antidepressant medications in a clinical panel study of patients with a major depressive disorder, with 200 having previously received a TCA and 219 an SSRI.

RESULTS

Analyses indicated decreased SSRI effectiveness with age in those with the melancholic subtype. TCA effectiveness appeared uninfluenced by age and depressive subtype.

CONCLUSION

Findings suggest why the broader-based TCAs may be more effective than the SSRIs in implicating age and depressive subtype influences.

摘要

目的

探讨血清素再摄取抑制剂（SSRI）类抗抑郁药总体上可能不如三环类（TCA）抗抑郁药有效的一种潜在机制。

方法

在一项针对重度抑郁症患者的临床小组研究中，临床精神科医生对既往抗抑郁药物的疗效进行了评估，其中200人曾服用过TCA，219人曾服用过SSRI。

结果

分析表明，在忧郁型亚型患者中，SSRI的疗效随年龄增长而降低。TCA的疗效似乎不受年龄和抑郁亚型的影响。

结论

研究结果表明了为何更具广泛适用性的TCA在涉及年龄和抑郁亚型影响方面可能比SSRI更有效。

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