哮喘儿童在乙酰甲胆碱激发试验后即刻呼出一氧化氮水平降低。
Reduction in exhaled nitric oxide immediately after methacholine challenge in asthmatic children.
作者信息
Piacentini G L, Bodini A, Peroni D G, Miraglia del Giudice M, Costella S, Boner A L
机构信息
Clinica Pediatrica, Università di Verona, Italy.
出版信息
Thorax. 2002 Sep;57(9):771-3. doi: 10.1136/thorax.57.9.771.
Abstract
BACKGROUND
The measurement of exhaled nitric oxide (NO) has recently been proposed as a useful technique for the evaluation of airway inflammation in asthma. The purpose of this study was to determine the effect of methacholine bronchial provocation on the levels of exhaled NO in asthmatic children.
METHOD
Exhaled NO was measurement immediately before and after methacholine provocation in 51 children with mild to moderate asthma.
RESULTS
A significant decrease occurred in the level of exhaled NO (p<0.0001) after methacholine bronchial provocation which was not correlated with the percentage fall in forced expiratory volume in 1 second (FEV(1)).
CONCLUSIONS
The methacholine test should not be used immediately before measurement of exhaled NO in children with asthma.
摘要
背景
呼出一氧化氮（NO）的测量最近被提议作为评估哮喘气道炎症的一种有用技术。本研究的目的是确定乙酰甲胆碱支气管激发试验对哮喘儿童呼出NO水平的影响。
方法
对51例轻至中度哮喘儿童在乙酰甲胆碱激发试验前后立即测量呼出NO。
结果
乙酰甲胆碱支气管激发试验后呼出NO水平显著下降（p<0.0001），且与1秒用力呼气容积（FEV(1)）下降百分比无关。
结论
对于哮喘儿童，在测量呼出NO之前不应立即进行乙酰甲胆碱试验。
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