伊拉地平对有或无慢性灌注缺陷的可卡因戒除者脑血流的增强作用。

Isradipine enhancement of cerebral blood flow in abstinent cocaine abusers with and without chronic perfusion deficits.

作者信息

Gottschalk P C H, Kosten Thomas R

机构信息

Department of Psychiatry, Yale University School of Medicine and the VA Connecticut Healthcare System, West Haven, Conn 06516, USA.

出版信息

Am J Addict. 2002 Summer;11(3):200-8. doi: 10.1080/10550490290087983.

DOI:10.1080/10550490290087983

PMID:12202012

Abstract

Nine cocaine abusers with cerebral blood flow (CBF) deficits (hypo-perfused areas) on HMPAO SPECT scans were compared to six without these deficits after six doses of isradipine (5 mg TID). When comparing the scan before isradipine to that after using SPM analysis, the ratio of hypo- to hyper-fusion showed a 16% increase in the maximum Z scores and 30% fewer areas of hypo-perfusion among those cocaine abusers with deficits. These deficits may represent segmental cerebral vasospasm that was reversed by this vasodilating agent in cocaine abusers with areas of hypo-perfusion (deficits) as baseline.

摘要

对9名在HMPAO单光子发射计算机断层扫描（SPECT）中显示有脑血流量（CBF）不足（灌注不足区域）的可卡因滥用者，与6名没有这些不足的可卡因滥用者，在给予6剂伊拉地平（每日3次，每次5毫克）后进行了比较。在使用统计参数映射（SPM）分析比较服用伊拉地平前与服用后的扫描结果时，在有灌注不足的可卡因滥用者中，灌注不足与灌注过度的比率显示，最大Z值增加了16%，灌注不足区域减少了30%。这些不足可能代表节段性脑血管痉挛，在以灌注不足区域（不足）为基线的可卡因滥用者中，这种血管扩张剂可逆转这种痉挛。