果蝇锌指转录因子CF2是肌肉发育过程中MEF2下游的一种成肌标志物。
The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development.
作者信息
Bagni Claudia, Bray Sarah, Gogos Joseph A, Kafatos Fotis C, Hsu Tien
机构信息
European Molecular Biology Laboratory, Heidelberg, D-69117, Germany.
出版信息
Mech Dev. 2002 Sep;117(1-2):265-8. doi: 10.1016/s0925-4773(02)00176-4.
The Drosophila C(2)-H(2)-type zinc-finger transcription factor CF2 has been shown to regulate follicular cell fate determination during oogenesis. Here we show that CF2 is also expressed in the developing muscles of the embryo where it first appears at stage 12 at the time of skeletal myoblast fusion. Later it is expressed in all muscle lineages including skeletal, visceral and cardiac. Epistatic analysis showed that CF2 expression is dependent on the myogenic factor MEF2.
果蝇C(2)-H(2)型锌指转录因子CF2已被证明在卵子发生过程中调节卵泡细胞命运的决定。在此我们表明，CF2在胚胎发育中的肌肉中也有表达，它在第12阶段骨骼肌成肌细胞融合时首次出现。随后它在所有肌肉谱系中表达，包括骨骼肌、内脏肌和心肌。上位性分析表明，CF2的表达依赖于肌源性因子MEF2。
Zotero 插件