晚期帕金森病苍白球慢性刺激的长期随访
Long-term follow-up of globus pallidus chronic stimulation in advanced Parkinson's disease.
作者信息
Durif Franck, Lemaire Jean-Jacques, Debilly Bérengère, Dordain Gérard
机构信息
Fédération de Neurologie, Hôpital Gabriel Montpied, Clermont Ferrand, France.
出版信息
Mov Disord. 2002 Jul;17(4):803-7. doi: 10.1002/mds.10128.
To assess the long-term follow-up of the globus pallidus internus (GPi) stimulation, six patients were evaluated every year by using the Unified Parkinson's Disease Rating Scale (UPDRS). Three years postoperatively, GPi stimulation led to a significant improvement of dyskinesia severity (50%, P = 0.05) and activities of daily living (subscore of quality of life scale, 9%, P = 0.05). However, the improvement induced by chronic pallidal stimulation on the mean daily duration in the off state was lost at the last assessment.
为评估内侧苍白球（GPi）刺激的长期随访情况，每年使用统一帕金森病评定量表（UPDRS）对6例患者进行评估。术后3年，GPi刺激使运动障碍严重程度显著改善（50%，P = 0.05），日常生活活动能力（生活质量量表子评分，9%，P = 0.05）也得到改善。然而，在最后一次评估时，慢性苍白球刺激对平均每日关期时长的改善作用消失了。
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