使用（18）F-FDG的基于混合相机的PET/CT系统对癌症患者进行功能和结构联合评估。

Combined functional and structural evaluation of cancer patients with a hybrid camera-based PET/CT system using (18)F-FDG.

作者信息

Israel Ora, Mor Maya, Gaitini Diana, Keidar Zohar, Guralnik Luda, Engel Ahuva, Frenkel Alex, Bar-Shalom Rachel, Kuten Abraham

机构信息

Department of Nuclear Medicine, Rambam Medical Center, Haifa, Israel.

出版信息

J Nucl Med. 2002 Sep;43(9):1129-36.

PMID:12215549

Abstract

UNLABELLED

Correct diagnosis and definition of the functional and anatomic status of lesions in cancer patients are of clinical importance. The value of hybrid imaging using a gamma camera-based PET/CT and (18)F-FDG in determining the relationship between mass and cancer was assessed.

METHODS

Hybrid imaging was performed using a device combining low-dose CT and gamma camera-based PET. Ninety-one patients with histologically proven malignancy and 190 suspected sites of disease were evaluated. Camera-based PET was performed after the injection of 296-370 MBq (18)F-FDG. The presence of organomegaly or an abnormal mass on CT and of abnormal uptake of (18)F-FDG was assessed for each suspected lesion. The presence of malignancy at each site was determined by biopsy, imaging follow-up, or clinical outcome.

RESULTS

Five imaging patterns were found. Pattern 1 showed congruent abnormal (18)F-FDG uptake and a mass on CT in 110 of the lesions. One hundred two sites (93%) had active cancer. Pattern 2 showed a mass on CT, larger than the area of abnormal (18)F-FDG uptake, and was found in 5 lesions. Active malignancy was proven in 3 sites (60%). Pattern 3 showed an abnormal mass on CT with no (18)F-FDG uptake and was found in 52 lesions. Thirteen of these lesions (25%) had active tumor. Pattern 4 showing abnormal (18)F-FDG uptake with no mass on CT was found in 23 lesions. Sixteen of these sites (70%) were malignant. Pattern 5 showed normal CT findings and no abnormal (18)F-FDG uptake in 11 patients. Two of these patients (18%) had active disease. Hybrid imaging was of value in establishing the correct relationship between CT and (18)F-FDG findings in 98 of the 190 lesions (52%).

CONCLUSION

A range of patterns presenting with or without abnormal (18)F-FDG uptake on camera-based PET and a mass on CT may occur in suspected cancer sites. Both structural changes on CT and increased cell metabolism expressed by abnormal (18)F-FDG uptake should be considered in oncologic imaging. Hybrid imaging, a combined physiologic and anatomic modality, appears to provide new diagnostic opportunities in characterizing function and morphology in malignancies.

摘要

未标注

准确诊断并明确癌症患者病变的功能和解剖状态具有临床重要性。评估了基于γ相机的PET/CT和（18）F-FDG混合成像在确定肿块与癌症之间关系方面的价值。

方法

使用结合低剂量CT和基于γ相机的PET的设备进行混合成像。对91例经组织学证实为恶性肿瘤的患者和190个可疑病变部位进行了评估。在注射296 - 370 MBq（18）F-FDG后进行基于相机的PET检查。对每个可疑病变评估CT上是否存在器官肿大或异常肿块以及（18）F-FDG的异常摄取情况。通过活检、影像学随访或临床结果确定每个部位是否存在恶性肿瘤。

结果

发现了五种成像模式。模式1在110个病变中显示（18）F-FDG摄取异常且CT上有肿块。102个部位（93%）存在活动性癌症。模式2显示CT上有肿块，大于（18）F-FDG摄取异常的区域，在5个病变中发现。3个部位（60%）证实有活动性恶性肿瘤。模式3显示CT上有异常肿块但无（18）F-FDG摄取，在52个病变中发现。其中13个病变（25%）有活动性肿瘤。模式4显示（18）F-FDG摄取异常但CT上无肿块，在23个病变中发现。其中16个部位（70%）为恶性。模式5在11例患者中显示CT结果正常且无（18）F-FDG摄取异常。其中2例患者（18%）有活动性疾病。混合成像在190个病变中的98个（52%）中对于确立CT与（18）F-FDG结果之间的正确关系有价值。