Diedrich O, Kraft C N, Sasse J, Zhou H, Lüring C
Rheinische Friedrich-Wilhelms-Universität, Klinik und Poliklinik für Orthopädie, Sigmund-Freud-Strasse 25, 53105 Bonn.
Unfallchirurg. 2002 Jul;105(7):651-5. doi: 10.1007/s00113-001-0396-x.
The most frequent form of bone infection is haematogenous osteomyelitis (HOM), typically affecting infants and children. Dependent on the virulence of the pathogen and the patients immune response, one can distinguish between the acute (AHOM) and primary subacute haematogenous osteomyelitis (PSHO). In contrast to AHOM, diagnosis of PSHO is severely impeded in that clinical and blood-chemistry findings usually do not enable differentiation from primary malignant bone tumors. With a comparable age predilection and clinical symptoms, as well as very similar conventional radiographic, MRI- and bone-scan-findings, the most important differential diagnosis is Ewing's-sarcoma. The here demonstrated case of a 12 year-old girl shows that PSHA may imitate a sarcoma very closely, even concerning such usually fairly reliable radiographic aspects like osteolysis and lamellar periostal bone reaction. Despite the use of MRI, the diagnosis initially remained uncertain and a malignant bony lesion could only be ruled out after open biopsy and histopathological evaluation.
骨感染最常见的形式是血源性骨髓炎(HOM),通常影响婴幼儿和儿童。根据病原体的毒力和患者的免疫反应,可以区分急性血源性骨髓炎(AHOM)和原发性亚急性血源性骨髓炎(PSHO)。与AHOM不同,PSHO的诊断严重受阻,因为临床和血液化学检查结果通常无法与原发性恶性骨肿瘤相鉴别。由于具有相似的年龄偏好和临床症状,以及非常相似的传统X线、MRI和骨扫描结果,最重要的鉴别诊断是尤因肉瘤。这里展示的一名12岁女孩的病例表明,PSHA可能非常酷似肉瘤,甚至在诸如骨质溶解和层状骨膜骨反应等通常相当可靠的影像学表现方面也是如此。尽管使用了MRI,最初诊断仍不确定,只有在开放活检和组织病理学评估后才能排除恶性骨病变。