表达吲哚胺2,3-双加氧酶的人树突状细胞的潜在调节功能。

Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase.

作者信息

Munn David H, Sharma Madhav D, Lee Jeffrey R, Jhaver Kanchan G, Johnson Theodore S, Keskin Derin B, Marshall Brendan, Chandler Phillip, Antonia Scott J, Burgess Russell, Slingluff Craig L, Mellor Andrew L

机构信息

Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA.

出版信息

Science. 2002 Sep 13;297(5588):1867-70. doi: 10.1126/science.1073514.

DOI:10.1126/science.1073514

PMID:12228717

Abstract

Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.

摘要

抗原呈递细胞（APC）可诱导免疫耐受或免疫反应。我们描述了人类APC的一个亚群，该亚群表达吲哚胺2,3-双加氧酶（IDO）并在体外抑制T细胞增殖。IDO阳性APC构成了一个离散的亚群，可通过细胞表面标志物CD123和CCR6的共表达来鉴定。在树突状细胞（DC）谱系中，IDO介导的抑制活性在完全成熟以及未成熟的CD123 + DC中均存在。在体内也可以很容易地检测到IDO + DC，这表明这些细胞可能代表人类APC的一个调节亚群。