Kruspe Rachel, Broussard Amy, Santanilla Jairo, Gupta Shaminder, Espinoza Carmen, Lopez Fred A, Kantrow Steven
J La State Med Soc. 2002 Jul-Aug;154(4):178-81; quiz 181-2.
Anticonvulsant hypersensitivity syndrome is a systemic illness that presents most commonly as a triad of fever, rash, and lymphadenopathy in a patient exposed to one or more of the aromatic antiepileptic drugs (phenytoin, phenobarbital, and carbamazepine). Although generally self-limited, the syndrome may be life-threatening, particularly among patients who develop severe cutaneous eruptions or hepatitis. Early recognition of the syndrome is essential, as immediate discontinuation of the offending antiepileptic agent is the most important step in improving outcome. We present a case of anticonvulsant hypersensitivity syndrome in a patient with a previous history of Hodgkin's lymphoma.
抗惊厥药超敏反应综合征是一种全身性疾病,在接触一种或多种芳香族抗癫痫药物(苯妥英钠、苯巴比妥和卡马西平)的患者中,最常见的表现为发热、皮疹和淋巴结病三联征。尽管该综合征通常为自限性,但可能危及生命,尤其是在出现严重皮肤疹或肝炎的患者中。早期识别该综合征至关重要,因为立即停用引起问题的抗癫痫药物是改善预后的最重要步骤。我们报告一例既往有霍奇金淋巴瘤病史的患者发生抗惊厥药超敏反应综合征的病例。