[与使用99m锝-巯基乙酰三甘氨酸测定相对肾功能相关的方法学方面]
[Methodological aspects related to the determination of the relative renal function using 99mTC MAG3].
作者信息
Ladrón De Guevara Hernández D, Ham H, Franken P, Piepsz A, Lobo Sotomayor G
机构信息
Hospital San Juan de Dios, Unidad de Medicina Nuclear, Santiago, Chile. Akademisch Ziekenhuis, Free University of Brussels, Dept of Nuclear Medicine, Brussels, Belgium.
出版信息
Rev Esp Med Nucl. 2002 Sep-Oct;21(5):338-42. doi: 10.1016/s0212-6982(02)72104-6.
UNLABELLED
The aim of the study was to evaluate three different methods for calculating the split renal function in patients with only one functioning kidney, keeping in mind that the split function should be zero on the side of the non-functioning kidney.
PATIENTS
We retrospectively selected 28 99mTc MAG3 renograms performed in children, 12 with unilateral nephrectomy, 4 with unilateral agenesis and 12 with a non-functioning kidney.
METHODS
A renal and perirenal region of interest (ROI) were delineated around the functioning kidney. The ROIs around the empty kidney were drawn symmetrically to the contralateral side. The split renal function was calculated using three different methods, the integral method, the slope method and the Patlak-Rutland algorithm.
RESULTS
For the whole group of 28 kidneys as well as for the three categories of patients, the three methods provided a split function on the side of the non-functioning kidney close to the zero value, regardless of whether the empty kidney was the left or the right one.
CONCLUSION
We recommend the use of the integral method for the whole range of split renal function with 99mTc MAG3. No significant improvement was obtained by means of the more sophisticated Patlak-Rutland method.
未标注
本研究的目的是评估三种不同的方法来计算仅有一个功能肾的患者的分肾功能，同时要记住无功能肾一侧的分肾功能应为零。
患者
我们回顾性选取了28例儿童的99mTc MAG3肾图，其中12例为单侧肾切除术，4例为单侧肾缺如，12例为无功能肾。
方法
在功能肾周围划定肾脏和肾周感兴趣区（ROI）。无功能肾周围的ROI以对侧为对称绘制。使用三种不同方法计算分肾功能，即积分法、斜率法和Patlak-Rutland算法。
结果
对于28个肾脏的整个组以及三类患者，无论无功能肾是左侧还是右侧，这三种方法在无功能肾一侧提供的分肾功能都接近零值。
结论
我们建议在使用99mTc MAG3进行分肾功能计算的整个范围内采用积分法。更复杂的Patlak-Rutland方法未获得显著改善。
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