释放一氧化氮的非甾体抗炎药及相关一氧化氮供体药物的药理学与潜在治疗应用
Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs.
作者信息
Keeble J E, Moore P K
机构信息
Centre for Cardiovascular Biology and Medicine, King's College, University of London, Guy's Campus, London SE1 9RT.
出版信息
Br J Pharmacol. 2002 Oct;137(3):295-310. doi: 10.1038/sj.bjp.0704876.
This review examines the biological significance, therapeutic potential and mechanism(s) of action of a range of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAID) and related nitric oxide-releasing donating drugs (NODD). The slow release of nitric oxide (NO) from these compounds leads to subtle changes in the profile of pharmacological activity of the parent, non-steroidal anti-inflammatory drugs (NSAID). For example, compared with NSAID, NO-NSAID cause markedly diminished gastrointestinal toxicity and improved anti-inflammatory and anti-nociceptive efficacy. In addition, nitroparacetamol exhibits hepatoprotection as opposed to the hepatotoxic activity of paracetamol. The possibility that NO-NSAID or NODD may be of therapeutic benefit in a wide variety of disease states including pain and inflammation, thrombosis and restenosis, neurodegenerative diseases of the central nervous system, colitis, cancer, urinary incontinence, liver disease, impotence, bronchial asthma and osteoporosis is discussed.
本综述探讨了一系列释放一氧化氮的非甾体抗炎药（NO-NSAID）及相关释放一氧化氮的供体药物（NODD）的生物学意义、治疗潜力及作用机制。这些化合物缓慢释放一氧化氮（NO）会使母体非甾体抗炎药（NSAID）的药理活性特征发生细微变化。例如，与NSAID相比，NO-NSAID导致胃肠道毒性显著降低，抗炎和抗伤害感受疗效提高。此外，与对乙酰氨基酚的肝毒性活性相反，硝基对乙酰氨基酚具有肝保护作用。文中讨论了NO-NSAID或NODD在多种疾病状态下可能具有治疗益处的可能性，这些疾病包括疼痛与炎症、血栓形成与再狭窄、中枢神经系统神经退行性疾病、结肠炎、癌症、尿失禁、肝病、阳痿、支气管哮喘和骨质疏松症。
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