Vayá Amparo, López José María, Contreras María Teresa, Falcó Cristina, Arguedas Joaquín, Corella Dolores, Aznar Justo
Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain.
Clin Hemorheol Microcirc. 2002;27(1):17-25.
In order to ascertain whether erythrocyte deformability (ED) is involved in chronic coronary syndromes, this rheological property was determined in 92 survivors of acute myocardial infarction (AMI) who had had the acute event 3 years ago and in 150 volunteers. From the 92 AMI survivors in 50 (43 males, 7 females aged 61+/-9 years) ED was determined with filtrometric techniques (Hanss Hemorheometre) and in 42 (32 males, 10 females aged 63+/-11 years) with laser diffractometric ones (Rheodyn SSD). The control group consisted of 66 and 84 volunteers whose ED was measured with the above mentioned devices respectively. Patients and controls were matched for age, sex, total cholesterol and triglyceride levels. With the Hanss Hemorheometre, the Rigidity Index (RI) was higher in patients than in controls (9.4+/-1.2 vs 8.7+/-1.5; p=0.01) although after adjusting for confounding variables (MCV and leukocyte count) in a logistic regression analysis the RI was no longer statistically significant. With the Rheodyn SSD the Erythrocyte Elongation Index (EEI) determined at 12, 30 and 60 Pa, did not show statistically significant differences between cases and controls at any of the shear stresses tested. Our results suggest that AMI survivors who had had the ischemic event 3 years ago do not show decrease RBC deformability with either of the two methodologies used. Red blood cell deformability does not appear to contribute to impaired microcirculatory blood flow in chronic coronary syndromes.
为了确定红细胞变形性（ED）是否与慢性冠状动脉综合征有关，对92名3年前发生急性心肌梗死（AMI）的幸存者和150名志愿者进行了这项流变学特性测定。在92名AMI幸存者中，50名（43名男性，7名女性，年龄61±9岁）采用滤过测定技术（Hanss血液流变仪）测定ED，42名（32名男性，10名女性，年龄63±11岁）采用激光衍射测定技术（Rheodyn SSD）测定ED。对照组由66名和84名志愿者组成，分别用上述设备测量其ED。患者和对照组在年龄、性别、总胆固醇和甘油三酯水平上相匹配。使用Hanss血液流变仪时，患者的刚性指数（RI）高于对照组（9.4±1.2对8.7±1.5；p = 0.01），尽管在逻辑回归分析中对混杂变量（平均红细胞体积和白细胞计数）进行调整后，RI不再具有统计学意义。使用Rheodyn SSD时，在12、30和60 Pa下测定的红细胞伸长指数（EEI）在任何测试的剪切应力下，病例组和对照组之间均未显示出统计学显著差异。我们的结果表明，3年前发生缺血事件的AMI幸存者，使用两种方法中的任何一种都未显示红细胞变形性降低。红细胞变形性似乎对慢性冠状动脉综合征中受损的微循环血流没有影响。
