Montesani Chiara, D'Amato Alberto, Santella Sergio, Pronio Annamaria, Giovannini Cristiano, Cristaldi Mario, Ribotta Giorgio
Università degli Studi di Roma La Sapienza, Policlinico Umberto I, VI Clinica Chirurgica, Roma, Italy.
Hepatogastroenterology. 2002 Sep-Oct;49(47):1469-73.
BACKGROUND/AIMS: The aim of this study was to evaluate functional results after Billroth I, Billroth II and Roux-en-Y reconstruction in subtotal gastrectomy.
Forty-five patients were randomized between 1990 and 1995 and stratified in 3 different groups: 15 BI, 15 BII and 15 Roux. They were investigated by esophagogastroduodenoscopy with multiple biopsies and upper gastrointestinal scintiscanning, to evaluate gastroesophageal reflux and dynamics of gastric emptying. They also answered a questionnaire: Gastrointestinal Quality of Life. Index.
A reflux esophagitis was found in 5 BI, in 7 BII and in 2 Roux (p < 0.001). No gastric lesions were found in 6 BI, in 5 BII and in 12 Roux, (BI vs. Y, p < 0.05; BII vs. Y, p < 0.001). Chronic superficial gastritis was present in 9 BI, in 4 BII and in 3 Roux (BI vs. Y, p < 0.05). Dynamic scintiscan demonstrated the presence of gastroesophageal reflux in 5 BI and gastric emptying was fast (37' < T 1/2 < 86'), but incomplete (60' residual activity: 49-62%). Gastroesophageal reflux was evident in 7 BII with slow (28' < T 1/2 < 143') and incomplete (60' residual activity: 48-72%) gastric emptying. Gastroesophageal reflux was detected in 2 Roux and radioactive bolus progression in the Roux limb was fast (24' < T 1/2 < 53') and complete (60' residual activity: 42-52%) (BI vs. Y; BII vs. Y, p < 0.001). There was no statistical significance between Gastrointestinal Quality of Life Index score in the 3 groups.
The Authors affirm that Roux-en-Y is the technique of choice in subtotal gastrectomy, if compared with BI and BII.
背景/目的:本研究旨在评估胃大部切除术中毕Ⅰ式、毕Ⅱ式和Roux-en-Y重建术后的功能结果。
1990年至1995年间,45例患者被随机分组并分为3组:15例毕Ⅰ式(BI)、15例毕Ⅱ式(BII)和15例Roux式。通过食管胃十二指肠镜检查及多次活检和上消化道闪烁扫描对他们进行研究,以评估胃食管反流和胃排空动力学。他们还回答了一份问卷:胃肠道生活质量指数。
毕Ⅰ式中有5例发现反流性食管炎,毕Ⅱ式中有7例,Roux式中有2例(p<0.001)。毕Ⅰ式中有6例、毕Ⅱ式中有5例、Roux式中有12例未发现胃部病变(毕Ⅰ式与Roux式比较,p<0.05;毕Ⅱ式与Roux式比较,p<0.001)。毕Ⅰ式中有9例、毕Ⅱ式中有4例、Roux式中有3例存在慢性浅表性胃炎(毕Ⅰ式与Roux式比较,p<0.05)。动态闪烁扫描显示毕Ⅰ式中有5例存在胃食管反流,胃排空快(37'<T 1/2<86'),但不完全(60'残留活性:49%-62%)。毕Ⅱ式中有7例胃食管反流明显,胃排空慢(28'<T 1/2<143')且不完全(60'残留活性:48%-72%)。Roux式中有2例检测到胃食管反流,Roux袢内放射性团块推进快(24'<T 1/2<53')且完全(60'残留活性:42%-52%)(毕Ⅰ式与Roux式比较;毕Ⅱ式与Roux式比较,p<0.001)。3组胃肠道生活质量指数评分之间无统计学意义。
作者认为,与毕Ⅰ式和毕Ⅱ式相比,Roux-en-Y是胃大部切除术中的首选术式。