由5-氟尿嘧啶、亚叶酸钙、依托泊苷和顺二氯二氨铂组成的联合化疗方案用于治疗晚期胃癌。
Combination chemotherapy comprising 5-fluorouracil, leucovorin, etoposide, and cis-diamminedichloroplatinum for the treatment of advanced gastric cancer.
作者信息
Mochizuki Fumiro, Fujii Masashi, Kasakura Yuichi, Yamagata Motoo, Kochi Mitsugu, Wakabayashi Kazuhiko, Kanamori Noriaki, Takayama Tadatoshi
机构信息
Third Department of Surgery, Nihon University School of Medicine, 30-1 Oyaguchikami-machi, Itabashi-ku, Tokyo 173-8610, Japan.
出版信息
J Cancer Res Clin Oncol. 2002 Sep;128(9):493-6. doi: 10.1007/s00432-002-0369-7. Epub 2002 Aug 22.
PURPOSE
The FLEP regimen (5-FU, LV, ETP, and CDDP) has been recommended as a combination chemotherapy to control advanced and recurrent gastric cancer. We performed a phase II study of this regimen in 49 patients with advanced gastric cancer.
METHODS
The treatment regimen consisted of: 5-FU at 370 mg/m(2) (days 1-5, i.v. 24 h); LV at a dose of 30 mg (days 1-5, i.v. bolus); and ETP and CDDP each at 70 mg/m(2) (days 7 and 21, i.a. 2 h), which was repeated every five weeks.
RESULTS
The overall response rate was 40.8% (20/49 patients) and the median survival time was 12.6 months (range 1.1-41.8). The adverse events were Grade 3/4 leukocytopenia (16.3%), Grade 3/4 thrombocytopenia (8.2%), Grade 3 nausea and/or vomiting (4.1%), and Grade 3 stomatitis (2.0%).
CONCLUSIONS
Based on the encouraging response rate and prognosis, we recommend applying the FLEP regimen to patients with primary advanced gastric cancer.
目的
FLEP方案（5-氟尿嘧啶、亚叶酸钙、依托泊苷和顺铂）已被推荐作为控制晚期和复发性胃癌的联合化疗方案。我们对49例晚期胃癌患者进行了该方案的II期研究。
方法
治疗方案包括：5-氟尿嘧啶370mg/m²（第1 - 5天，静脉滴注24小时）；亚叶酸钙剂量为30mg（第1 - 5天，静脉推注）；依托泊苷和顺铂各70mg/m²（第7天和第21天，动脉注射2小时），每五周重复一次。
结果
总缓解率为40.8%（20/49例患者），中位生存时间为12.6个月（范围1.1 - 41.8个月）。不良事件包括3/4级白细胞减少（16.3%）、3/4级血小板减少（8.2%）、3级恶心和/或呕吐（4.1%）以及3级口腔炎（2.0%）。
结论
基于令人鼓舞的缓解率和预后，我们建议将FLEP方案应用于原发性晚期胃癌患者。
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