Ozturk Vesile, Cakmur Raif, Donmez Berril, Yener Gorsev Gulmen, Kursad Fatma, Idiman Fethi
Dokuz Eylül University, Medical School, Department of Neurology, 35340, Izmir, Turkey.
J Neurol. 2002 Sep;249(9):1268-71. doi: 10.1007/s00415-002-0834-x.
We studied the excitability of the motor cortex in patients with migraine without aura (MWOA) (n = 20) and with chronic migraine (CM) (n = 20) using transcranial magnetic stimulation (TMS). By using a 90-mm circular coil placed over the vertex and recording of the first dorsal interosseous muscle, we measured thresholds, latencies and amplitudes of motor evoked potentials and duration of cortical silent periods in patient groups and in controls (n = 20). No differences were found between groups for threshold, latency and amplitude values. However, the duration of the cortical silent period was longer in CM patients, being significantly different from both controls and MWOA. We suggest that either this difference in cortical excitability may develop during transformation from MWOA to CM or different pathophysiological mechanisms may play a role in these two headache syndromes.
我们使用经颅磁刺激（TMS）研究了无先兆偏头痛（MWOA）患者（n = 20）和慢性偏头痛（CM）患者（n = 20）的运动皮层兴奋性。通过将一个90毫米的圆形线圈置于头顶，并记录第一背侧骨间肌的活动，我们测量了患者组和对照组（n = 20）的运动诱发电位的阈值、潜伏期和波幅以及皮层静息期的持续时间。在阈值、潜伏期和波幅数值方面，各组之间未发现差异。然而，CM患者的皮层静息期持续时间更长，与对照组和MWOA患者均有显著差异。我们认为，这种皮层兴奋性的差异可能在从MWOA转变为CM的过程中出现，或者不同的病理生理机制可能在这两种头痛综合征中发挥作用。
