Male contraception: the effect of d-norgestrel and testosterone enanthate on spermatogenesis--ultrastructural characteristics.

Electron microscopy was performed on testicular biopsies from men during a contraceptive regimen with d-norgestrel and testosterone enanthate. There was a considerable reduction of spermatogenesis, the seminiferous tubules being lined with a low epithelium of early spermatogenetic cells and only few late stages and spermatozoa. At the ultrastructural level, no qualitative changes could be observed in any of the tubular cells, a fact that seems to be of significance in contraception where any possible change should be entirely reversible.