Kampman Kyle M, Pettinati Helen, Volpicelli Joseph, Kaempf Gail, Turk Ellen, Insua Ambrose, Lipkin Craig, Sparkman Thorne, O'Brien Charles P
Department of Psychiatry, University of Pennsylvania School of Medicine and the Department of Veterans Affairs Medical Center, Philadelphia, USA.
J Addict Dis. 2002;21(4):13-26. doi: 10.1300/J069v21n04_02.
This study compares alcohol withdrawal severity during outpatient detoxification in alcohol dependent subjects (ALC) and in subjects dependent on both alcohol and cocaine (ALC/COC). Subjects included 123 ALC and 66 ALC/COC subjects. Baseline demographic and drug use variables, alcohol withdrawal symptoms, and the total amount of oxazepam taken during alcohol detoxification were compared between the two groups. Compared to ALC subjects, ALC/COC subjects were younger, more likely to be African-American, and had less severe histories of alcohol dependence. However, alcohol withdrawal symptom severity did not differ significantly between the two groups. Nevertheless, controlling for differences in alcohol use history, ALC/COC subjects still received less oxazepam than did ALC subjects to treat alcohol withdrawal symptoms. Despite similar intensity of alcohol withdrawal symptoms, ALC/COC subjects received less oxazepam to treat alcohol withdrawal symptoms compared to ALC subjects. Both subject and clinician factors may explain the difference in oxazepam use.
本研究比较了酒精依赖者（ALC）和酒精与可卡因双重依赖者（ALC/COC）在门诊戒酒脱毒期间的酒精戒断严重程度。研究对象包括123名ALC受试者和66名ALC/COC受试者。比较了两组之间的基线人口统计学和药物使用变量、酒精戒断症状以及酒精脱毒期间服用的奥沙西泮总量。与ALC受试者相比，ALC/COC受试者更年轻，更有可能是非裔美国人，且酒精依赖史的严重程度较低。然而，两组之间的酒精戒断症状严重程度没有显著差异。尽管如此，在控制酒精使用史差异后，ALC/COC受试者在治疗酒精戒断症状时服用的奥沙西泮仍比ALC受试者少。尽管酒精戒断症状强度相似，但与ALC受试者相比，ALC/COC受试者在治疗酒精戒断症状时服用的奥沙西泮较少。受试者因素和临床医生因素都可能解释奥沙西泮使用上的差异。
