与抗神经元细胞核抗体1型自身抗体及胸腺瘤相关的副肿瘤性神经自身免疫病

Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma.

作者信息

Vernino Steven, Eggenberger Eric R, Rogers Lisa R, Lennon Vanda A

机构信息

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

出版信息

Neurology. 2002 Sep 24;59(6):929-32. doi: 10.1212/wnl.59.6.929.

DOI:10.1212/wnl.59.6.929

PMID:12297583

Abstract

Neurologic autoimmunity frequently occurs with thymoma, particularly myasthenia gravis and skeletal muscle-specific autoantibodies. Type 1 antineuronal nuclear antibody (ANNA-1/"anti-Hu"), which is recognized as an immunoglobulin G marker of small-cell lung carcinoma, has not been reported with thymoma. The authors identified four patients (three under age 40) with ANNA-1 and a paraneoplastic neurologic complication of thymoma. Retrospective testing of stored serum from 172 patients with thymoma revealed ANNA-1 in 3%. This report extends the oncologic implications of ANNA-1 seropositivity.

摘要

神经自身免疫常与胸腺瘤伴发，尤其是重症肌无力和骨骼肌特异性自身抗体。1型抗神经元核抗体（ANNA-1/“抗Hu”）被认为是小细胞肺癌的免疫球蛋白G标志物，尚未见有与胸腺瘤相关的报道。作者发现了4例患有ANNA-1且伴有胸腺瘤副肿瘤性神经并发症的患者（3例年龄在40岁以下）。对172例胸腺瘤患者储存血清的回顾性检测发现，3%的患者存在ANNA-1。本报告扩展了ANNA-1血清阳性的肿瘤学意义。