Hughes I E, Ilett K F, Jellett L B
Br J Clin Pharmacol. 1975 Dec;2(6):521-5. doi: 10.1111/j.1365-2125.1975.tb00570.x.
The uptake of quinidine by washed human red blood cells from isotonic buffer solution (pH 7.4) occurred rapidly and was proportional to the concentration of drug in buffer. A constant red cell/buffer partition ratio of 4.16+/-0.15 s.e. mean was found. 2. Uptake from buffer solution was not affected by temperature or ouabain or by gassing with nitrogen or carbon monoxide and there was no evidence of saturability. Drug in red blood cells was associated largely with the cell contents (94.4+/-1.5% s.e. mean) following partition. 3 Plasma reduced the uptake of quinidine so that a red cell/plasma partition ratio of 0.82+/-0.09 s.e. mean was found. 4 Alteration of plasma binding by dilution of plasma with buffer showed that uptake was proportional to free drug concentration. 5 The possibility of red cell uptake of drug should be included in any considerations concerning pharmacokinetic aspects of drug action in the body.
从等渗缓冲溶液（pH 7.4）中洗过的人红细胞对奎尼丁的摄取迅速，且与缓冲液中药物浓度成正比。发现红细胞/缓冲液的恒定分配比为4.16±0.15（标准误均值）。2. 从缓冲溶液中的摄取不受温度、哇巴因影响，也不受用氮气或一氧化碳通气的影响，且没有饱和性的证据。在分配后，红细胞中的药物主要与细胞内容物相关（94.4±1.5%，标准误均值）。3. 血浆降低了奎尼丁的摄取，因此发现红细胞/血浆分配比为0.82±0.09（标准误均值）。4. 用缓冲液稀释血浆改变血浆结合表明，摄取与游离药物浓度成正比。5. 在任何关于药物在体内作用的药代动力学方面的考虑中，都应包括红细胞摄取药物的可能性。
