Kyger E R, Chiariello L, Hallman G L, Cooley D A
Ann Thorac Surg. 1975 Mar;19(3):277-88. doi: 10.1016/s0003-4975(10)64018-0.
Evaluation was made of 17 patients who underwent conduit reconstruction of the right ventricular outflow tract (for anomalies other than truncus arteriosus) at the Texas Heart Institute between December, 1965, and June, 1974. Fifteen patients survived the operation and have shown substantial clinical improvement. Several different conduits were used, principally an allograft aorta with the aortic valve and mitral leaflet attached, a woven Dacron prosthesis containing a xenograft (porcine) valve, and a valveless Dacron tube graft. Allograft conduits are sometimes difficult to procure and keep and tend to calcify with passage of time. Woven Dacron prostheses are favored because they are readily available in a wide range of sizes. We believe it is not necessary for the conduit to contain a valve unless the patient has pulmonary hypertension, in which case we use a xenograft (porcine) valve because this valve does not require the long-term use of anticoagulants, a difficult regimen to manage in children. The largest possible prosthesis must be used; otherwise right ventricular hypertension will persist. Indications for conduit reconstruction include anomalous coronary arteries crossing the right ventricular outflow tract, discontinuity of the pulmonary arteries, and pulmonary atresia with a ventricular septal defect. Our current method of managing pulmonary atresia with ventricular septal defect (pseudotruncus arteriosus) includes palliative shunting to relieve hypoxemia during infancy and to permit full development of the pulmonary arteries for eventual total correction at a more optimal age when a larger conduit may be used.
对1965年12月至1974年6月期间在德克萨斯心脏研究所接受右心室流出道管道重建术(针对动脉干以外的畸形)的17例患者进行了评估。15例患者术后存活,临床症状有显著改善。使用了几种不同的管道,主要是带有主动脉瓣和二尖瓣叶的同种异体主动脉、含有异种移植(猪)瓣膜的编织涤纶假体以及无瓣膜的涤纶管型移植体。同种异体管道有时难以获取和保存,且会随着时间推移而钙化。编织涤纶假体更受青睐,因为它们有多种尺寸可供选择。我们认为,除非患者患有肺动脉高压,否则管道不一定需要有瓣膜,在这种情况下,我们使用异种移植(猪)瓣膜,因为这种瓣膜不需要长期使用抗凝剂,而这对儿童来说是难以管理的治疗方案。必须使用尽可能大的假体;否则右心室高压将持续存在。管道重建的适应症包括横跨右心室流出道的异常冠状动脉、肺动脉中断以及室间隔缺损合并肺动脉闭锁。我们目前治疗室间隔缺损合并肺动脉闭锁(假性动脉干)的方法包括在婴儿期进行姑息性分流以缓解低氧血症,并使肺动脉充分发育,以便在更合适的年龄进行最终的完全矫正,届时可使用更大的管道。