Griffiths C T
Natl Cancer Inst Monogr. 1975 Oct;42:101-4.
The effect of tumor bulk resection on survival was studied in 102 patients with stages II and III ovarian cancer. A multiple linear regression equation provuded both simultenaous control of multiple confounding variables and an assessment of these variables as independent predictors of survival. The most important factors were the histologic grade of the tumor and the size of the largest residual tumor mass after operation. Survival time was uniformly poor if the diameter of the largest residual tumor mass exceeded 1.5 cm irrespective of total tumor volume (mean=12.7 months, SE=1.6 mo). Survival time was inversely proportional to residual mass size under 1.6 cm, and surgery improved survival relative to reduction in mass size below this limit. Extensive resections of tumor bulk with failure to remove all masses greater than 1.5 cm in diameter did not influence survival. Surgery provides optimum benefit when all gross tumor can be excised safely.
对102例II期和III期卵巢癌患者研究了肿瘤大块切除对生存的影响。一个多元线性回归方程既可以同时控制多个混杂变量，又可以评估这些变量作为生存的独立预测因素。最重要的因素是肿瘤的组织学分级和术后最大残留肿瘤块的大小。如果最大残留肿瘤块的直径超过1.5厘米，无论肿瘤总体积如何，生存时间均较差（平均=12.7个月，标准误=1.6个月）。在1.6厘米以下，生存时间与残留肿块大小成反比，相对于低于此限度的肿块大小减小，手术可改善生存。对肿瘤大块进行广泛切除但未能切除所有直径大于1.5厘米的肿块并不影响生存。当所有肉眼可见肿瘤能够安全切除时，手术可带来最佳获益。
