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非H-2基因型对H-2连锁混合淋巴细胞反应刺激(MLR-S)基因反应的影响。

Influence of non-H-2 genotype on the response to H-2-linked mixed lymphocyte reaction stimulating (MLR-S) genes.

作者信息

Rychlíková M, Démant P

出版信息

Folia Biol (Praha). 1975;21(1):65-9.

PMID:123514
Abstract

The intensity of the mixed lymphocyte reaction to H-2-linked mixed lymphocyte reaction stimulating genes is influenced by non-H-2 genotype. The same H-2 incompatibility results in a stronger mixed lymphocyte reaction when both partners have the C57BL/10ScSnPh genetic background than when they have the genetic background of the A/Ph strain. It is suggested that, as in man, the intensity of the mixed lymphocyte reaction to incompatibility at the MLR-S genes linked to the major histocompatibility complex is controlled by MLR-response genes not linked to MHS.

摘要

对与H-2连锁的混合淋巴细胞反应刺激基因的混合淋巴细胞反应强度受非H-2基因型影响。当双方都具有C57BL/10ScSnPh遗传背景时,相同的H-2不相容性所导致的混合淋巴细胞反应比双方具有A/Ph品系遗传背景时更强。有人提出,如同在人类中一样,对与主要组织相容性复合体连锁的MLR-S基因不相容性的混合淋巴细胞反应强度由与MHS不连锁的MLR反应基因控制。

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