Runx3控制本体感觉背根神经节神经元的轴突投射。
Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons.
作者信息
Inoue Ken-ichi, Ozaki Shigeru, Shiga Takashi, Ito Kosei, Masuda Tomoyuki, Okado Nobuo, Iseda Tsutomu, Kawaguchi Saburo, Ogawa Masaharu, Bae Suk-Chul, Yamashita Namiko, Itohara Shigeyoshi, Kudo Norio, Ito Yoshiaki
机构信息
Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
出版信息
Nat Neurosci. 2002 Oct;5(10):946-54. doi: 10.1038/nn925.
Dorsal root ganglion (DRG) neurons specifically project axons to central and peripheral targets according to their sensory modality. The Runt-related genes Runx1 and Runx3 are expressed in DRG neuronal subpopulations, suggesting that they may regulate the trajectories of specific axons. Here we report that Runx3-deficient (Runx3(-/-)) mice displayed severe motor uncoordination and that few DRG neurons synthesized the proprioceptive neuronal marker parvalbumin. Proprioceptive afferent axons failed to project to their targets in the spinal cord as well as those in the muscle. NT-3-responsive Runx3(-/-) DRG neurons showed less neurite outgrowth in vitro. However, we found no changes in the fate specification of Runx3(-/-) DRG neurons or in the number of DRG neurons that expressed trkC. Our data demonstrate that Runx3 is critical in regulating the axonal projections of a specific subpopulation of DRG neurons.
背根神经节（DRG）神经元根据其感觉模式将轴突特异性投射到中枢和外周靶点。与Runt相关的基因Runx1和Runx3在DRG神经元亚群中表达，这表明它们可能调节特定轴突的轨迹。在此，我们报告Runx3基因缺陷（Runx3(-/-)）小鼠表现出严重的运动不协调，并且很少有DRG神经元合成本体感觉神经元标志物小白蛋白。本体感觉传入轴突无法投射到脊髓中的靶点以及肌肉中的靶点。对NT-3有反应的Runx3(-/-) DRG神经元在体外显示出较少的神经突生长。然而，我们发现Runx3(-/-) DRG神经元的命运特化或表达trkC的DRG神经元数量没有变化。我们的数据表明，Runx3在调节DRG神经元特定亚群的轴突投射中起关键作用。
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