Robins Perry, Gupta Aditya K
New York University, New York, USA.
Cutis. 2002 Aug;70(2 Suppl):4-7.
Actinic keratosis (AK) is a lesion induced by UV radiation, affecting predominantly fair-skinned individuals with a history of excessive sun exposure. Because AKs are potentially cancerous, management of AKs is important for dermatologists. The most frequently performed procedure for AKs is excision or destruction of the lesion, followed by biopsy. Topical fluorouracil creams are an efficient, effective treatment, especially for large quantities of widespread lesions. However, fluorouracil can produce an inflammatory facial reaction that is associated with the destruction of AKs. A new formulation, 0.5% fluorouracil cream, is indicated for once-daily use with a duration of treatment of up to 4 weeks. This regimen may be more cost-effective than the higher concentrations of fluorouracil creams (5% and 1%, respectively), which specify twice-daily application. Less frequent applications also may improve patient compliance with topical fluorouracil treatment. The use of 0.5% fluorouracil cream may provide an effective, safe, and economical option to augment the available treatments of AK, which include liquid nitrogen cryotherapy and 5% and 1% fluorouracil creams.
光化性角化病（AK）是一种由紫外线辐射引起的病变，主要影响有过度日晒史的白皮肤个体。由于AK有潜在癌变风险，因此对皮肤科医生来说，AK的治疗很重要。治疗AK最常用的方法是切除或破坏病变组织，然后进行活检。外用氟尿嘧啶乳膏是一种有效、高效的治疗方法，尤其适用于大量广泛分布的病变。然而，氟尿嘧啶会引起面部炎症反应，这与AK的破坏有关。一种新配方的0.5%氟尿嘧啶乳膏，适用于每日一次使用，治疗时长可达4周。这种治疗方案可能比更高浓度的氟尿嘧啶乳膏（分别为5%和1%）更具成本效益，后者规定每日使用两次。减少用药频率也可能提高患者对外用氟尿嘧啶治疗的依从性。使用0.5%氟尿嘧啶乳膏可能为增强现有的AK治疗方法（包括液氮冷冻疗法以及5%和1%氟尿嘧啶乳膏）提供一种有效、安全且经济的选择。
