Gupta Aditya K, Cooper Elizabeth A, Feldman Steven R, Fleischer Alan B
Department of Medicine, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada.
Cutis. 2002 Aug;70(2 Suppl):8-13.
Although actinic keratosis (AK) has been linked to the development of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), increased awareness regarding diagnosis and treatment may be an important component for reducing morbidity and even mortality from AK and NMSC. We used the National Ambulatory Medical Care Survey (NAMCS) data from 1990 to 1999 to evaluate the diagnosis and treatment of AKs among a wide variety of patients by physicians across the United States. To our knowledge, no widespread surveys of North American populations have been performed recently to determine the epidemiology of AK. AK was diagnosed in more than 47 million visits over the 10-year period surveyed and was found to occur in 14% of patients visiting dermatologists. The diagnosis of AK as determined by NAMCS does not reflect the true prevalence of AK because only patients seeking physician diagnosis were surveyed. This suggests that the actual number of patients in the United States with AK is much higher than 14%. Rates of AK diagnosis in the standard metropolitan statistical areas (SMSAs) and non-standard metropolitan statistical areas (non-SMSAs) of the West states are higher than in other states, but geographic location may not be a direct risk factor for the development of AKs. Procedures were undertaken at 70% of visits where AK was the primary diagnosis. Destruction of lesions was the most frequently performed procedure found in the survey considering only the 1993 and 1994 NAMCS data. Biopsy was the second most frequently performed procedure.
尽管光化性角化病(AK)与非黑素瘤皮肤癌(NMSC)的发生有关,尤其是鳞状细胞癌(SCC),但提高对其诊断和治疗的认识可能是降低AK和NMSC发病率甚至死亡率的重要因素。我们使用了1990年至1999年的国家门诊医疗调查(NAMCS)数据,以评估美国各地医生对各类患者中AK的诊断和治疗情况。据我们所知,最近尚未对北美人群进行广泛调查以确定AK的流行病学情况。在调查的10年期间,超过4700万人次就诊时被诊断出患有AK,并且发现14%就诊于皮肤科医生的患者患有该病。NAMCS确定的AK诊断并不能反映AK的真实患病率,因为仅对寻求医生诊断的患者进行了调查。这表明美国实际患有AK的患者数量远高于14%。西部各州的标准大都市统计区(SMSA)和非标准大都市统计区(非SMSA)的AK诊断率高于其他州,但地理位置可能不是AK发生的直接风险因素。在以AK为主要诊断的就诊中,70%进行了相关治疗。仅考虑1993年和1994年的NAMCS数据,病变破坏是调查中最常进行的治疗方法。活检是第二常进行的治疗方法。