Moy Linda, Slanetz Priscilla J, Moore Richard, Satija Sameer, Yeh Eren D, McCarthy Kathleen A, Hall Deborah, Staffa Mary, Rafferty Elizabeth A, Halpern Elkan, Kopans Daniel B
Breast Imaging Center, New York University School of Medicine, 530 First Ave, FPT Suite 8N, New York, NY 10016-6497, USA.
Radiology. 2002 Oct;225(1):176-81. doi: 10.1148/radiol.2251010999.
To determine the number of patients who received a diagnosis of breast cancer after having an area of clinical concern at presentation and combined negative mammographic and ultrasonographic (US) findings.
During a 4-year period, 829 patients with a palpable abnormality at presentation and combined negative mammographic and US findings were identified. The number of women who went on to receive a diagnosis of breast cancer was determined retrospectively. The authors searched the breast imaging database and the pathology database, sent a contact letter to the referring physicians, and linked their data to the State Cancer Registry. They also analyzed the breast parenchymal density among all patients who had more than 2 years of follow-up.
Of the 829 women, 374 had follow-up information. Two-hundred thirty-three patients had negative imaging findings with more than 2 years of follow-up. The other 141 women were presumed to be cancer free, as they were not identified by the State Cancer Registry. Six (2.6%) of the 233 women had a diagnosis of breast cancer in the area of the palpable abnormality. The six cancers were diagnosed among the 156 women who had radiographically dense breast tissue (Breast Imaging Reporting and Data System category 3 or 4). Among the 77 women with predominantly fatty tissues, no cancers were diagnosed.
A negative mammographic and US finding of a palpable abnormality does not exclude breast cancer, but the likelihood of breast cancer is low, approximately 2.6%-2.7%. It may be higher if the breast tissues are dense and lower if they are predominantly fatty.
确定在初诊时存在临床可疑区域且乳腺钼靶和超声（US）检查结果均为阴性的情况下被诊断为乳腺癌的患者数量。
在4年期间，共识别出829例初诊时可触及异常且乳腺钼靶和US检查结果均为阴性的患者。回顾性确定后续被诊断为乳腺癌的女性数量。作者检索了乳腺影像数据库和病理数据库，给转诊医生发送了联系函，并将他们的数据与国家癌症登记处进行了关联。他们还分析了所有随访超过2年的患者的乳腺实质密度。
829名女性中，374名有随访信息。233名患者影像检查结果为阴性且随访超过2年。另外141名女性被认为无癌症，因为国家癌症登记处未识别出她们。233名女性中有6名（2.6%）在可触及异常区域被诊断为乳腺癌。这6例癌症是在156名乳腺组织呈放射致密型（乳腺影像报告和数据系统分类为3类或4类）的女性中诊断出来的。在77名主要为脂肪组织的女性中，未诊断出癌症。
乳腺钼靶和US检查对可触及异常结果为阴性并不能排除乳腺癌，但患乳腺癌的可能性较低，约为2.6% - 2.7%。如果乳腺组织致密，可能性可能更高；如果主要为脂肪组织，可能性则更低。
